Assay and functional analysis of dynamin-like Mx proteins

被引：33

作者：

Kochs, G

Reichelt, M

Danino, D

Hinshaw, JE

Haller, O

机构：

[1] Univ Freiburg, Dept Virol, Freiburg, Germany

[2] Technion Israel Inst Technol, Dept Biotechnol & Food Engn, Haifa, Israel

来源：

GTPASES REGULATING MEMBRANE DYNAMICS | 2005年 / 404卷

关键词：

D O I：

10.1016/S0076-6879(05)04055-3

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Mx proteins are interferon-induced large guanosin triphosphatases (GTPases) that share structural and functional properties with dynamin and dynamin-like proteins, such as self-assembly and association with intracellular membranes. A unique property of some Mx proteins is their antiviral activity against a range of RNA viruses, including influenza viruses and members of the bunyavirus family. These viruses are inhibited at an early stage in their life cycle, soon after host cell entry and before genome amplification. The association of the human MxA GTPase with membranes of the endoplasmic reticulum seems to support its antiviral function by providing an interaction platform that facilitates viral target recognition, MxA oligomerization, and missorting of the resulting multiprotein complex into large intracellular aggregates.

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收藏

页码：632 / 643

页数：12

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