Accommodating fluorinated amino acids in a helical peptide environment

被引：20

作者：

Nyakatura, Elisabeth K. ^{[1
]}

Reimann, Oliver ^{[1
]}

Vagt, Toni ^{[2
]}

Salwiczek, Mario ^{[1
]}

Koksch, Beate ^{[1
]}

机构：

[1] Free Univ Berlin, Inst Chem & Biochem Organ Chem, D-14195 Berlin, Germany

[2] ETH, Inst Mol Biol & Biophys, CH-8093 Zurich, Switzerland

来源：

RSC ADVANCES | 2013年 / 3卷 / 18期

关键词：

COILED-COILS; PHAGE DISPLAY; OLIGOMERIZATION STATE; BUNDLE PROTEIN; STABILITY; DESIGN; HEXAFLUOROLEUCINE; POSITION;

D O I：

10.1039/c3ra41110a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Fluorinated amino acids represent useful building blocks for structural and functional upgrading of peptides and proteins. Here, we report the identification of a suitable environment for fluorinated aminobutyric acids in a central d-position of a heterodimeric coiled-coil assembly via phage display.

引用

页码：6319 / 6322

页数：4

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