Atherosclerosis and proteinase activation

被引：182

作者：

Dollery, CM

Libby, P

机构：

[1] Ctr Cardiovasc Biol & Med, Div Med, Rayne Inst, London WC1E 6JJ, England

[2] Brigham & Womens Hosp, Leducq Transatlantic Network Excellence Atherothr, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Boston, MA 02115 USA

来源：

CARDIOVASCULAR RESEARCH | 2006年 / 69卷 / 03期

关键词：

atherosclerosis; metalloproteinase; plaque; matrix;

D O I：

10.1016/j.cardiores.2005.11.003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Rapidly accumulating evidence points to the matrix metalloproteinases (MMPs) as major molecular mediators of arterial diseases. Findings from human pathological specimens, animals, and cell and molecular biology implicate matrix metalloproteinases in all stages of atherosclerosis including lesion initiation and progression and ultimately in plaque complication and triggering of thrombosis. The complex interactions within the proteolytic cascade allow multiple levels of control over these functions. This review weighs the evidence for the role of MMPs in arterial biology with particular reference to their activation in the atherosclerotic plaque. (c) 2005 European Society of Cardiology. Published by Elsevier B.V. All rights reserved.

引用

页码：625 / 635

页数：11

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