Model Systems for Cardiovascular Regenerative Biology

被引：26

作者：

Garbern, Jessica C. ^{[1
]}

Mummery, Christine L. ^{[2
]}

Lee, Richard T. ^{[3
,4
]}

机构：

[1] Boston Childrens Hosp, Boston, MA 02115 USA

[2] Leiden Univ, Med Ctr, Dept Anat & Embryol, NL-2300 RC Leiden, Netherlands

[3] Brigham & Womens Hosp, Cambridge, MA 02139 USA

[4] Partners Res Facil, Cambridge, MA 02139 USA

来源：

COLD SPRING HARBOR PERSPECTIVES IN MEDICINE | 2013年 / 3卷 / 04期

关键词：

EMBRYONIC STEM-CELLS; CARDIOMYOCYTE PROGENITOR CELLS; ZEBRAFISH HEART REGENERATION; CARDIOSPHERE-DERIVED CELLS; LARGE ANIMAL-MODELS; CARDIAC-MUSCLE; MYOCARDIAL-INFARCTION; IN-VITRO; COMPUTATIONAL MODEL; ADULT NEWT;

D O I：

10.1101/cshperspect.a014019

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

100103 [病原生物学]; 100218 [急诊医学];

摘要：

There is an urgent clinical need to develop new therapeutic approaches to treat heart failure, but the biology of cardiovascular regeneration is complex. Model systems are required to advance our understanding of biological mechanisms of cardiac regeneration as well as to test therapeutic approaches to regenerate tissue and restore cardiac function following injury. An ideal model system should be inexpensive, easily manipulated, easily reproducible, physiologically representative of human disease, and ethically sound. In this review, we discuss computational, cell-based, tissue, and animal models that have been used to elucidate mechanisms of cardiovascular regenerative biology or to test proposed therapeutic methods to restore cardiac function following disease or injury.

引用

页数：17

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