Synthesis of heterocycles via sequential Pd/Ru-catalysed allene insertion-nucleophile incorporation-olefin metathesis

被引：17

作者：

Dondas, HA

Balme, G

Blandine, C

Grigg, R ^{[1
]}

Hodgeson, A

Morris, J

Sridharan, V

机构：

[1] Univ Leeds, Sch Chem, Mol Innovat Divers & Automated Synth Ctr MIDAS, Leeds LS2 9JT, W Yorkshire, England

[2] Univ Lyon 1, Chim Organ Lab, F-69622 Villeurbanne, France

[3] GlaxoSmithKline, Proc R&D, Dartford DA1 5HA, Kent, England

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 49期

基金：

英国工程与自然科学研究理事会;

关键词：

D O I：

10.1016/S0040-4039(01)01810-X

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A novel sequential palladium/ruthenium-catalysed three-component process is described involving allenylation of aryl/heteroaryl iodides to generate (pi -allyl) palladium species which are intercepted by nitrogen nucleophiles to afford 1,6- and 1,7-dienes. Subsequent ring-closing metathesis affords N-heterocycles in good yield. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：8673 / 8675

页数：3

共 13 条

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