Histone deacetylases and cancer

被引：391

作者：

Barneda-Zahonero, Bruna ^{[1
]}

Parra, Maribel ^{[1
]}

机构：

[1] Bellvitge Biomed Res Inst IDIBELL, Cellular Differentiat Grp, Canc Epigenet & Biol Program PEBC, Barcelona 08908, Spain

来源：

MOLECULAR ONCOLOGY | 2012年 / 6卷 / 06期

关键词：

Protein acetylation; Histone deacetylases; Cancer; HUMAN BREAST-CANCER; CLASS-II; DIFFERENTIAL EXPRESSION; GENE-EXPRESSION; HEPATOCELLULAR-CARCINOMA; PRECLINICAL ACTIVITY; CELL-PROLIFERATION; DOWN-REGULATION; HDAC INHIBITOR; POOR-PROGNOSIS;

D O I：

10.1016/j.molonc.2012.07.003

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Reversible acetylation of histone and non-histone proteins is one of the most abundant post-translational modifications in eukaryotic cells. Protein acetylation and deacetylation are achieved by the antagonistic actions of two families of enzymes, histone acetyltransferases (HATs) and histone deacetylases (HDACs). Aberrant protein acetylation, particularly on histones, has been related to cancer while abnormal expression of HDACs has been found in a broad range of cancer types. Therefore, HDACs have emerged as promising targets in cancer therapeutics, and the development of HDAC inhibitors (HDIs), a rapidly evolving area of clinical research. However, the contributions of specific HDACs to a given cancer type remain incompletely understood. The aim of this review is to summarize the current knowledge concerning the role of HDACs in cancer with special emphasis on what we have learned from the analysis of patient samples. (c) 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

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页码：579 / 589

页数：11

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