Antifungal steroidal glycosides from the Patagonian starfish Anasterias minuta:: Structure-activity correlations

被引：46

作者：

Chludil, HD

Seldes, AM

Maier, MS

机构：

[1] Univ Buenos Aires, Fac Ciencias Exactas & Nat, Dept Quim Organ, RA-1428 Buenos Aires, DF, Argentina

[2] Univ Nacl Patagonia, Fac Ciencias Nat, Dept Quim, RA-9000 Chubut, Argentina

来源：

JOURNAL OF NATURAL PRODUCTS | 2002年 / 65卷 / 02期

关键词：

D O I：

10.1021/np010332x

中图分类号：

Q94 [植物学];

学科分类号：

071001 [植物学];

摘要：

Two new sulfated steroidal hexaglycosides, anasterosides A (2) and B (3), along with the known versicoside A (1) have been isolated from the Patagonian starfish Anasterias minuta. Their structures have been elucidated by spectroscopic analysis (NMR and FABMS) and chemical transformations. Compounds 1 and 2 and the synthetic pentaglycoside 1b derived from versicoside A showed antifungal activity against the plant pathogenic fungus Cladosporium cucumerinum. Desulfation of hexaglycoside 1 rendered a totally inactive, saponin.

引用

页码：153 / 157

页数：5

共 25 条

[11]

Iorizzi M, 1999, NATURALLY OCCURRING GLYCOSIDES, P345

[12]

ITAKURA Y, 1983, LIEBIGS ANN CHEM, P2079

[13]

KIM YC, 1992, LIEBIGS ANN CHEM, P453

[14]

KITAGAWA I, 1977, TETRAHEDRON LETT, P859

[15]

KREBS HC, 1984, LIEBIGS ANN CHEM, P296

[16]

Isolation and structure of glucosylceramides from the starfish Cosmasterias lurida [J].

Maier, MS ;

Kuriss, A ;

Seldes, AM .

LIPIDS, 1998, 33 (08) :825-827

[17]

Two new cytotoxic and virucidal trisulfated triterpene glycosides from the antarctic sea cucumber Staurocucumis liouvillei [J].

Maier, MS ;

Roccatagliata, AJ ;

Kuriss, A ;

Chludil, H ;

Seldes, AM ;

Pujol, CA ;

Damonte, EB .

JOURNAL OF NATURAL PRODUCTS, 2001, 64 (06) :732-736

[18]

BRINE SHRIMP - A CONVENIENT GENERAL BIOASSAY FOR ACTIVE-PLANT CONSTITUENTS [J].

MEYER, BN ;

FERRIGNI, NR ;

PUTNAM, JE ;

JACOBSEN, LB ;

NICHOLS, DE ;

MCLAUGHLIN, JL .

PLANTA MEDICA, 1982, 45 (01) :31-34

[19]

Minale L, 1993, Fortschr Chem Org Naturst, V62, P75

[20]

NAKAMURA K, 1988, CHEM PHARM BULL, V36, P2808

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