Stat1-dependent and -independent pathways in IFN-γ-dependent signaling

被引:487
作者
Ramana, CV
Gil, MP
Schreiber, RD
Stark, GR
机构
[1] Cleveland Clin Fdn, Lerner Res Inst, Cleveland, OH 44195 USA
[2] Washington Univ, Sch Med, Ctr Immunol, St Louis, MO 63110 USA
[3] Washington Univ, Sch Med, Dept Pathol, St Louis, MO 63110 USA
关键词
D O I
10.1016/S1471-4906(01)02118-4
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
The paradigm that emerged from studies during the past decade established a central role for Jak-Stat (signal transducer and activator of transcription) signaling pathways in promoting the diverse cellular responses induced by interferon gamma(IFN-gamma). However, recent studies have shown that the IFN-gamma receptor activates additional signaling pathways and can regulate gene expression by Stat1-independent pathways. The diversity of gene-expression patterns mediated by Stat1-dependent and -independent mechanisms and the balance between these two pathways play an important role in the biological response to IFN-gamma.
引用
收藏
页码:96 / 101
页数:6
相关论文
共 51 条
[1]   IFN-γ activates the C3G/Rap1 signaling pathway [J].
Alsayed, Y ;
Uddin, S ;
Ahmad, S ;
Majchrzak, B ;
Druker, BJ ;
Fish, EN ;
Platanias, LC .
JOURNAL OF IMMUNOLOGY, 2000, 164 (04) :1800-1806
[2]   The IFN gamma receptor: A paradigm for cytokine receptor signaling [J].
Bach, EA ;
Aguet, M ;
Schreiber, RD .
ANNUAL REVIEW OF IMMUNOLOGY, 1997, 15 :563-&
[3]   Cellular responses to interferon-gamma [J].
Boehm, U ;
Klamp, T ;
Groot, M ;
Howard, JC .
ANNUAL REVIEW OF IMMUNOLOGY, 1997, 15 :749-795
[4]   Kinase-negative mutants of JAK1 can sustain interferon-gamma-inducible gene expression but not an antiviral state [J].
Briscoe, J ;
Rogers, NC ;
Witthuhn, BA ;
Watling, D ;
Harpur, AG ;
Wilks, A ;
Stark, GR ;
Ihle, JN ;
Kerr, IM .
EMBO JOURNAL, 1996, 15 (04) :799-809
[5]   Fibroblasts regulate the switch from acute resolving to chronic persistent inflammation [J].
Buckley, CD ;
Pilling, D ;
Lord, JM ;
Akbar, AN ;
Scheel-Toellner, D ;
Salmon, M .
TRENDS IN IMMUNOLOGY, 2001, 22 (04) :199-204
[6]   Microarray analysis identifies interferon-inducible genes and Stat-1 as major transcriptional targets of human papillomavirus type 31 [J].
Chang, YJE ;
Laimins, LA .
JOURNAL OF VIROLOGY, 2000, 74 (09) :4174-4182
[7]   JAK-STAT PATHWAYS AND TRANSCRIPTIONAL ACTIVATION IN RESPONSE TO IFNS AND OTHER EXTRACELLULAR SIGNALING PROTEINS [J].
DARNELL, JE ;
KERR, IM ;
STARK, GR .
SCIENCE, 1994, 264 (5164) :1415-1421
[8]   STATs and gene regulation [J].
Darnell, JE .
SCIENCE, 1997, 277 (5332) :1630-1635
[9]   Serine phosphorylation of STATs [J].
Decker, T ;
Kovarik, P .
ONCOGENE, 2000, 19 (21) :2628-2637
[10]   Identification of genes differentially regulated by interferon α, β, or γ using oligonucleotide arrays [J].
Der, SD ;
Zhou, AM ;
Williams, BRG ;
Silverman, RH .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1998, 95 (26) :15623-15628