Fibroblasts regulate the switch from acute resolving to chronic persistent inflammation

被引：494

作者：

Buckley, CD ^{[1
]}

Pilling, D

Lord, JM

Akbar, AN

Scheel-Toellner, D

Salmon, M

机构：

[1] Univ Birmingham, Div Immun & Infect, MRC, Ctr Immune Regulat, Birmingham B15 2TT, W Midlands, England

[2] UCL Royal Free & Univ Coll Med Sch, Dept Clin Immunol, London NW3 2QG, England

来源：

TRENDS IN IMMUNOLOGY | 2001年 / 22卷 / 04期

关键词：

D O I：

10.1016/S1471-4906(01)01863-4

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Fibroblasts are important sentinel cells in the immune system and, here, it is proposed that these cells play a critical role in the switch from acute inflammation to adaptive immunity and tissue repair. It is suggested that chronic inflammation occurs because of disordered fibroblast behaviour in which failure to switch off their inflammatory programme leads to the inappropriate survival and retention of leukocytes within inflamed tissue.

引用

页码：199 / 204

页数：6

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