IFN-α and IFN-β: A link between immune memory and chronic inflammation

被引：115

作者：

Akbar, AN

Lord, JM

Salmon, M

机构：

[1] UCL Royal Free & Univ Coll Med Sch, Dept Clin Immunol, London NW3 2QG, England

[2] Univ Birmingham, MRC, Ctr Immunoregulat, Dept Immunol, Birmingham B15 2TT, W Midlands, England

[3] Univ Birmingham, MRC, Ctr Immunoregulat, Dept Rheumatol, Birmingham B15 2TT, W Midlands, England

来源：

IMMUNOLOGY TODAY | 2000年 / 21卷 / 07期

关键词：

D O I：

10.1016/S0167-5699(00)01652-2

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The majority of expanded T cells generated during an immune response are cleaned by apoptosis. Prevention of death in some activated T cells enables the persistence of a memory T-cell pool. Here, observations that IFN-alpha and IFN-beta inhibit activated T-cell apoptosis are described. Although this enables memory T cells to persist without antigen, excessive IFN-alpha ol IFN-gamma secretion might lead to chronic inflammation.

引用

页码：337 / +

页数：7

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