Tumour-suppressor genes - Killer in search of a motive?

被引：36

作者：

Clurman, B ^{[1
]}

Groudine, M ^{[1
]}

机构：

[1] UNIV WASHINGTON,SCH MED,SEATTLE,WA 98109

来源：

NATURE | 1997年 / 389卷 / 6647期

关键词：

D O I：

10.1038/38116

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The p53 protein is mutated in over 50% of human cancers, and has gained the title 'guardian of the genome' due to its crucial functions in regulating cell growth and death. A hitherto unknown protein, termed p73, has now been discovered and characterized, and it seems to share structural and functional similarity with p53. But more tests need to be done before p73 can be confirmed as a tumour-suppressor gene.

引用

页码：122 / 123

页数：2

共 9 条

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