Bcl-2 Proteins and Apoptosis: Choose Your Partner

被引：51

作者：

Shore, Gordon C. ^{[1
,2
]}

Nguyen, Mai ^{[1
,2
]}

机构：

[1] McGill Univ, Dept Biochem, Montreal, PQ H3G 1Y6, Canada

[2] McGill Univ, Goodman Canc Ctr, Montreal, PQ H3G 1Y6, Canada

来源：

CELL | 2008年 / 135卷 / 06期

关键词：

D O I：

10.1016/j.cell.2008.11.029

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The Bcl-2 family protein Bax is a key effector of apoptosis. Lovell et al. ( 2008) now describe the reconstitution and regulation in liposomes of tBid-mediated membrane penetration and oligomerization of Bax. These and other recent studies shed new light on the control of permeabilization of the mitochondrial outer membrane during apoptosis.

引用

页码：1004 / 1006

页数：3

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