A tumor-specific microRNA signature predicts survival in clear cell renal cell carcinoma

被引：39

作者：

Ge, Yu-Zheng ^{[1
]}

Wu, Ran ^{[1
]}

Xin, Hui ^{[1
]}

Zhu, Meng ^{[2
]}

Lu, Tian-Ze ^{[1
]}

Liu, Hao ^{[3
]}

Xu, Zheng ^{[1
]}

Yu, Peng ^{[4
]}

Zhao, You-Cai ^{[5
]}

Li, Ming-Hao ^{[1
,5
]}

Hu, Zhi-Kai ^{[1
]}

Zhao, Yan ^{[6
]}

Zhong, Bing ^{[7
]}

Xu, Xiao ^{[8
]}

Zhou, Liu-Hua ^{[1
]}

Xu, Lu-Wei ^{[1
]}

Wu, Jian-Ping ^{[1
]}

Li, Wen-Cheng ^{[1
]}

Zhu, Jia-Geng ^{[1
]}

Jia, Rui-Peng ^{[1
]}

机构：

[1] Nanjing Med Univ, Nanjing Hosp 1, Dept Pathol, Nanjing 210006, Jiangsu, Peoples R China

[2] Nanjing Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, MOE,Key Lab Modern Toxicol, Nanjing 210029, Jiangsu, Peoples R China

[3] Zhejiang Univ, Dept Urol, Sch Med, Affiliated Hosp 2, Hangzhou 310009, Peoples R China

[4] Nanchang Univ, Hosp Nanchang 1, Dept Urol, Nanchang 330008, Peoples R China

[5] Nanjing Med Univ, Nanjing Hosp 1, Dept Pathol, Nanjing 210006, Jiangsu, Peoples R China

[6] Jiangsu Univ, Xuzhou Peoples Hosp 3, Dept Urol, Xuzhou 221005, Peoples R China

[7] Nanjing Med Univ, Huaian Peoples Hosp 1, Dept Urol, Huaian 223300, Peoples R China

[8] JiangSu Armed Police Gen Hosp, Dept Radiat Oncol, Yangzhou 225003, Jiangsu, Peoples R China

来源：

JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY | 2015年 / 141卷 / 07期

基金：

中国国家自然科学基金;

关键词：

microRNA; Biomarker; Clear cell renal cell carcinoma; Prognosis; EXPRESSION; PROTEIN; IDENTIFICATION; CLASSIFICATION; EPIGENOMICS; BIOMARKER; GENOMICS;

D O I：

10.1007/s00432-015-1927-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Clear cell renal cell carcinoma (ccRCC) is the most common subtype of kidney cancers in adults, and microRNAs (miRNAs) differentially expressed in ccRCC tumors have been identified and proposed to predict prognosis. In the present study, we comprehensively analyzed the genome-wide miRNA expression profiles in ccRCC, with the aim to generate a tumor-specific miRNA signature of prognostic values. The miRNA profiles in tumor and the adjacent normal tissue were analyzed, and the association of the differentially expressed miRNAs with patient survival was examined with univariate Cox regression analysis. Finally, a tumor-specific miRNA signature was generated and examined with Kaplan-Meier survival, univariate, and multivariate Cox regression analyses. A total of 147 miRNAs were found differentially expressed between tumor and matched non-tumor tissues from 58 ccRCC patients. The prognostic values of these differentially expressed miRNAs were subsequently analyzed in the 411 ccRCC patients, and 22 miRNAs were found significantly correlated with patient survival. Finally, a tumor-specific miRNA signature of 22 miRNAs was generated and validated as an independent prognostic parameter. A tumor-specific miRNA signature consisting of 22 miRNAs was identified and validated as an independent prognostic factor, which could serve as a novel biomarker for ccRCC prognostication and help in predicting treatment outcome.

引用

页码：1291 / 1299

页数：9

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