Autologous Matrix-Induced Chondrogenesis (AMIC): Combining Microfracturing and a Collagen I/III Matrix for Articular Cartilage Resurfacing

被引:86
作者
Benthien, J. P. [1 ]
Behrens, P. [2 ]
机构
[1] Univ Basel, Dept Orthopaed Surg, CH-4031 Basel, Switzerland
[2] Univ Lubeck, Dept Orthopaed Surg, Lubeck, Germany
关键词
autologous cartilage repair; AMIC; microfracturing;
D O I
10.1177/1947603509360044
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
100224 [整形外科学];
摘要
Options for the treatment of cartilage defects include chondral resurfacing with abrasion, debridement, autologous chondrocyte transplantation (ACT), matrix-induced chondrocyte transplantation (MACI), or osteochondral autologous transplantation (OATS). This article describes the new method of autologous matrix-induced chondrogenesis (AMIC), a 1-step procedure combining subchondral microfracture with the fixation of a collagen I/III membrane by a partially autologous fibrin glue. Indications and contraindications are provided; a technical note is given. This method is primarily applied in osteochondral lesions of the knee and ankle joints; other joints may qualify.
引用
收藏
页码:65 / 68
页数:4
相关论文
共 11 条
[1]
Matrix-associated autologous chondrocyte transplantation (MACT). Minimally invasive technique in the knee [J].
Anders, Sven ;
Schaumburger, Jens ;
Schubert, Thomas ;
Grifka, Joachim ;
Behrens, Peter .
OPERATIVE ORTHOPADIE UND TRAUMATOLOGIE, 2008, 20 (03) :208-219
[2]
Autologous chondrocyte implantation versus matrix-induced autologous chondrocyte implantation for osteochondral defects of the knee [J].
Bartlett, W ;
Skinner, JA ;
Gooding, CR ;
Carrington, RWJ ;
Flanagan, AM ;
Briggs, TWR ;
Bentley, G .
JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME, 2005, 87B (05) :640-645
[3]
Matrix-associated autologous chondrocyte transplantation/implantation (MACT/MACI) - 5-year follow-up [J].
Behrens, Peter ;
Bitter, Thomas ;
Kurz, Bodo ;
Russlies, Martin .
KNEE, 2006, 13 (03) :194-202
[4]
Autologous chondrocyte implantation-technique and long-term follow-up [J].
Brittberg, Mats .
INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED, 2008, 39 :S40-S49
[5]
Migration pattern, morphology and viability of cells suspended in or sealed with fibrin glue:: A histomorphologic study [J].
Gille, J ;
Meisner, U ;
Ehlers, EM ;
Müller, A ;
Russlies, A ;
Behrens, P .
TISSUE & CELL, 2005, 37 (05) :339-348
[6]
Mechanical testing of fixation techniques for scaffold-based tissue-engineered grafts [J].
Knecht, Sven ;
Erggelet, Christoph ;
Endres, Michaela ;
Sittinger, Michael ;
Kaps, Christian ;
Stuessi, Edgar .
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS, 2007, 83B (01) :50-57
[7]
In vivo matrix-guided human mesenchymal stem cells [J].
Kramer, J ;
Böhrnsen, F ;
Lindner, U ;
Behrens, P ;
Schlenke, P ;
Rohwedel, J .
CELLULAR AND MOLECULAR LIFE SCIENCES, 2006, 63 (05) :616-626
[8]
The microfracture technique for the treatment of articular cartilage lesions in the knee - A prospective cohort study [J].
Mithoefer, K ;
Williams, RJ ;
Warren, RF ;
Potter, HG ;
Spock, CR ;
Jones, EC ;
Wickiewicz, TL ;
Marx, RG .
JOURNAL OF BONE AND JOINT SURGERY-AMERICAN VOLUME, 2005, 87A (09) :1911-1920
[9]
A cell-seeded biocomposite for cartilage repair [J].
Russlies, M ;
Behrens, P ;
Wünsch, L ;
Gille, J ;
Ehlers, EM .
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER, 2002, 184 (04) :317-323
[10]
Microfracture: Surgical technique and rehabilitation to treat chondral defects [J].
Steadman, JR ;
Rodkey, WG ;
Rodrigo, JJ .
CLINICAL ORTHOPAEDICS AND RELATED RESEARCH, 2001, (391) :S362-S369