Prostate cancer diagnosis in the new millennium: strengths and weaknesses of prostate-specific antigen and the discovery and clinical evaluation of prostate cancer gene 3 (PCA3)

被引：29

作者：

Kirby, Roger S. ^{[1
]}

Fitzpatrick, John M. ^{[2
,3
]}

Irani, Jacques ^{[4
]}

机构：

[1] Prostate Ctr, London W1G 8GT, England

[2] Mater Misericordiae Univ Hosp, Dublin 7, Ireland

[3] Univ Coll Dublin, Dublin 2, Ireland

[4] CHU La Miletrie, Poitiers, France

来源：

BJU INTERNATIONAL | 2009年 / 103卷 / 04期

关键词：

PSA; PCA3; prostate cancer; biopsy; decision; DIGITAL RECTAL EXAMINATION; MOLECULAR URINE ASSAY; UNITED-STATES; SERUM PSA; BIOPSY; PERFORMANCE; PREDICTOR; RISK; MEN;

D O I：

10.1111/j.1464-410X.2008.08280.x

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

The decision to take a prostate biopsy is traditionally guided by a digital rectal examination and measurement of serum total prostate-specific antigen (tPSA). However, both techniques are subject to inherent weaknesses. The prostate cancer gene 3 (PCA3), a gene-based marker, specific for prostate cancer, supplements the predictive power of tPSA to improve diagnosis of disease. Including this new marker in the standard of care for men at risk of prostate cancer should be considered, as it presents marked potential for better decision making for a prostate biopsy and for improving overall patient care.

引用

页码：441 / 445

页数：5

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