On the antibiotic activity of oxazolomycin

被引：25

作者：

Bagwell, Claire L. ^{[1
]}

Moloney, Mark G. ^{[1
]}

Thompson, Amber L. ^{[1
]}

机构：

[1] Univ Oxford, Dept Chem, Chem Res Lab, Oxford OX1 3TA, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 14期

关键词：

oxazolomycin; antibiotic; bioactivity; conformation;

D O I：

10.1016/j.bmcl.2008.05.105

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Structural analysis of oxazolomycin and simpler fragments containing a common 3-hydroxy-2,2-dimethylpropanamide moiety has indicated that a U-shaped conformation is preferred, in some cases stabilised by hydrogen bonding between the N-H and O-H residues, as shown by a combination of molecular modelling, NMR spectroscopic and single crystal X-ray analysis. A direct synthesis of this unit has been established via the opening of b-lactones by a range of amines, and their antibacterial activity been shown to vary with the hydrophobic character of the substituents. (c) 2008 Elsevier Ltd. All rights reserved.

引用

页码：4081 / 4086

页数：6

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