Polymorphism of human telomeric quadruplex structures

被引：356

作者：

Dai, Jixun ^{[1
]}

Carver, Megan ^{[1
]}

Yang, Danzhou ^{[1
,2
,3
]}

机构：

[1] Univ Arizona, Coll Pharm, Tucson, AZ 85721 USA

[2] Arizona Canc Ctr, Tucson, AZ 85724 USA

[3] Univ Arizona, Inst BIO5, Tucson, AZ 85721 USA

来源：

BIOCHIMIE | 2008年 / 90卷 / 08期

关键词：

human telomere; G-quadruplex; structure polymorphism; potassium structure; anticancer drug target; NMR;

D O I：

10.1016/j.biochi.2008.02.026

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human telomeric DNA consists of tandem repeats of the sequence cl(TTAGGG). Compounds that can stabilize the intramolecular DNA G-quadruplexes formed in the human telomeric sequence have been shown to inhibit the activity of telomerase and telomere maintenance, thus the telomeric DNA G-quadruplex has been considered as an attractive target for cancer therapeutic intervention. Knowledge of intramolecular human telomeric G-quadruplex structure(s) formed under physiological conditions is important for structure-based rational drug design and thus has been the subject of intense investigation. This review will give an overview of recent progress on the intramolecular human telomeric G-quadruplex structures formed in K+ solution. It will also give insight into the structure polymorphism. of human telomeric sequences and its implications for drug targeting. (C) 2008 Elsevier Masson SAS. All fights reserved.

引用

页码：1172 / 1183

页数：12

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[41] Long G tails at both ends of human chromosomes suggest a C strand degradation mechanism for telomere shortening [J].