Internal ribosome entry sites within the RNA genomes of hepatitis C virus and other flaviviruses

被引：69

作者：

Lemon, SM ^{[1
]}

Honda, M

机构：

[1] Univ Texas, Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA

[2] Kanazawa Univ, Sch Med, Dept Internal Med 1, Kanazawa, Ishikawa 920, Japan

来源：

SEMINARS IN VIROLOGY | 1997年 / 8卷 / 03期

关键词：

IRES; translation; ribosome; RNA structure; virus classification;

D O I：

10.1006/smvy.1997.0129

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The 5' nontranslated RNAs of hepatitis C virus (HCV) and several other members of the Flaviviridae contain highly structured segments which form internal ribosome entry sites (IRESs). These cia-active RNA elements direct the cap-independent initiation of translation of the viral polyprotein in association with trans-acting cellular and possibly viral proteins, and thus they play a key role in the replication of the virus. The structure of the HCV IRES does not resemble that of any picornaviral IRES, and its function is uniquely dependent upon RNA sequence extending 3' of the site of translation initiation as well as structure surrounding the initiator AUG. (C) 1997 Academic Press.

引用

页码：274 / 288

页数：15

共 53 条

[1] POLIOVIRUSES CONTAINING PICORNAVIRUS TYPE-1 AND/OR TYPE-2 INTERNAL RIBOSOMAL ENTRY SITE ELEMENTS - GENETIC HYBRIDS AND THE EXPRESSION OF A FOREIGN GENE [J].

ALEXANDER, L ;

LU, HH ;

WIMMER, E .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (04) :1406-1410

[2] INTERACTION OF POLYPYRIMIDINE TRACT-BINDING PROTEIN WITH THE 5'-NONCODING REGION OF THE HEPATITIS-C VIRUS-RNA GENOME AND ITS FUNCTIONAL REQUIREMENT IN INTERNAL INITIATION OF TRANSLATION [J].

ALI, N ;

SIDDIQUI, A .

JOURNAL OF VIROLOGY, 1995, 69 (10) :6367-6375

[3] The La antigen binds 5' noncoding region of the hepatitis C virus RNA in the context of the initiator AUG codon and stimulates internal ribosome entry site-mediated translation [J].

Ali, N ;

Siddiqui, A .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1997, 94 (06) :2249-2254

[4] DNA-POLYMERASE OF BACTERIOPHAGE-T4 IS AN AUTOGENOUS TRANSLATIONAL REPRESSOR [J].

ANDRAKE, M ;

GUILD, N ;

HSU, T ;

GOLD, L ;

TUERK, C ;

KARAM, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1988, 85 (21) :7942-7946

[5] CHARACTERIZATION OF THE AUTOANTIGEN-LA AS A NUCLEIC-ACID DEPENDENT ATPASE DATPASE WITH MELTING PROPERTIES [J].

BACHMANN, M ;

PFEIFER, K ;

SCHRODER, HC ;

MULLER, WEG .

CELL, 1990, 60 (01) :85-93

[6] Spatial structure and insertion capacity of immunodominant region of hepatitis B core antigen [J].

Borisova, G ;

Wanst, OB ;

Mezule, G ;

Skrastina, D ;

Petrovskis, I ;

Dislers, A ;

Pumpens, P ;

Grens, E .

INTERVIROLOGY, 1996, 39 (1-2) :16-22

[7] PICORNAVIRUS INTERNAL RIBOSOME ENTRY SEGMENTS - COMPARISON OF TRANSLATION EFFICIENCY AND THE REQUIREMENTS FOR OPTIMAL INTERNAL INITIATION OF TRANSLATION IN-VITRO [J].

BORMAN, AM ;

BAILLY, JL ;

GIRARD, M ;

KEAN, KM .

NUCLEIC ACIDS RESEARCH, 1995, 23 (18) :3656-3663

[8] SEQUENCES WITHIN THE POLIOVIRUS INTERNAL RIBOSOME ENTRY SEGMENT CONTROL VIRAL-RNA SYNTHESIS [J].

BORMAN, AM ;

DELIAT, FG ;

KEAN, KM .

EMBO JOURNAL, 1994, 13 (13) :3149-3157

[9] SECONDARY STRUCTURE OF THE 5' NONTRANSLATED REGIONS OF HEPATITIS-C VIRUS AND PESTIVIRUS GENOMIC RNAS [J].

BROWN, EA ;

ZHANG, HC ;

PING, LH ;

LEMON, SM .

NUCLEIC ACIDS RESEARCH, 1992, 20 (19) :5041-5045

[10] SEQUENCE-ANALYSIS OF THE 5' NONCODING REGION OF HEPATITIS-C VIRUS [J].

BUKH, J ;

PURCELL, RH ;

MILLER, RH .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (11) :4942-4946

← 1 2 3 4 5 6 →