Internal ribosome entry sites within the RNA genomes of hepatitis C virus and other flaviviruses

被引：69

作者：

Lemon, SM ^{[1
]}

Honda, M

机构：

[1] Univ Texas, Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA

[2] Kanazawa Univ, Sch Med, Dept Internal Med 1, Kanazawa, Ishikawa 920, Japan

来源：

SEMINARS IN VIROLOGY | 1997年 / 8卷 / 03期

关键词：

IRES; translation; ribosome; RNA structure; virus classification;

D O I：

10.1006/smvy.1997.0129

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The 5' nontranslated RNAs of hepatitis C virus (HCV) and several other members of the Flaviviridae contain highly structured segments which form internal ribosome entry sites (IRESs). These cia-active RNA elements direct the cap-independent initiation of translation of the viral polyprotein in association with trans-acting cellular and possibly viral proteins, and thus they play a key role in the replication of the virus. The structure of the HCV IRES does not resemble that of any picornaviral IRES, and its function is uniquely dependent upon RNA sequence extending 3' of the site of translation initiation as well as structure surrounding the initiator AUG. (C) 1997 Academic Press.

引用

页码：274 / 288

页数：15

共 53 条

[31] Porcine polypyrimidine tract-binding protein stimulates translation initiation at the internal ribosome entry site of foot-and-mouth-disease virus [J].

Niepmann, M .

FEBS LETTERS, 1996, 388 (01) :39-42

[32] PROKARYOTIC-LIKE CIS ELEMENTS IN THE CAP-INDEPENDENT INTERNAL INITIATION OF TRANSLATION ON PICORNAVIRUS RNA [J].

PILIPENKO, EV ;

GMYL, AP ;

MASLOVA, SV ;

SVITKIN, YV ;

SINYAKOV, AN ;

AGOL, VI .

CELL, 1992, 68 (01) :119-131

[33] PESTIVIRUS TRANSLATION INITIATION OCCURS BY INTERNAL RIBOSOME ENTRY [J].

POOLE, TL ;

WANG, CY ;

POPP, RA ;

POTGIETER, LND ;

SIDDIQUI, A ;

COLLETT, MS .

VIROLOGY, 1995, 206 (01) :750-754

[34] UNIQUE FEATURES OF INTERNAL INITIATION OF HEPATITIS-C VIRUS-RNA TRANSLATION [J].

REYNOLDS, JE ;

KAMINSKI, A ;

KETTINEN, HJ ;

GRACE, K ;

CLARKE, BE ;

CARROLL, AR ;

ROWLANDS, DJ ;

JACKSON, RJ .

EMBO JOURNAL, 1995, 14 (23) :6010-6020

[35]

Reynolds JE, 1996, RNA, V2, P867

[36] NUCLEOTIDE-SEQUENCE OF YELLOW-FEVER VIRUS - IMPLICATIONS FOR FLAVIVIRUS GENE-EXPRESSION AND EVOLUTION [J].

RICE, CM ;

LENCHES, EM ;

EDDY, SR ;

SHIN, SJ ;

SHEETS, RL ;

STRAUSS, JH .

SCIENCE, 1985, 229 (4715) :726-733

[37] ALMOST THE ENTIRE 5' NON-TRANSLATED REGION OF HEPATITIS-C VIRUS IS REQUIRED FOR CAP-INDEPENDENT TRANSLATION [J].

RIJNBRAND, R ;

BREDENBEEK, P ;

VANDERSTRAATEN, T ;

WHETTER, L ;

INCHAUSPE, G ;

LEMON, S ;

SPAAN, W .

FEBS LETTERS, 1995, 365 (2-3) :115-119

[38] Internal entry of ribosomes is directed by the 5' noncoding region of classical swine fever virus and is dependent on the presence of an RNA pseudoknot upstream of the initiation codon [J].

Rijnbrand, R ;

vanderStraaten, T ;

vanRijn, PA ;

Spaan, WJM ;

Bredenbeek, PJ .

JOURNAL OF VIROLOGY, 1997, 71 (01) :451-457

[39] The influence of AUG codons in the hepatitis C virus 5' nontranslated region on translation and mapping of the translation initiation window [J].

Rijnbrand, RCA ;

Abbink, TEM ;

Haasnoot, PCJ ;

Spaan, WJM ;

Bredenbeek, PJ .

VIROLOGY, 1996, 226 (01) :47-56

[40] Specific interaction of glyceraldehyde 3-phosphate dehydrogenase with the 5'-nontranslated RNA of hepatitis A virus [J].

Schultz, DE ;

Hardin, CC ;

Lemon, SM .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (24) :14134-14142

← 1 2 3 4 5 6 →