Oncogenic Ras and its role in tumor cell invasion and metastasis

被引：211

作者：

Campbell, PM ^{[1
]}

Der, CJ ^{[1
]}

机构：

[1] Univ N Carolina, Dept Pharmacol, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27599 USA

来源：

SEMINARS IN CANCER BIOLOGY | 2004年 / 14卷 / 02期

关键词：

Ras; oncogene; signaling; invasion; metastasis;

D O I：

10.1016/j.semcancer.2003.09.015

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The processes by which cancer cells leave the tumor and enter adjacent tissue is known as invasion, whereas metastasis refers to secondary tumor colonization of tissue at a distance from the primary lesion. These two events are the most lethal of cancer phenomena and the signaling mechanisms that govern them are complex. The Ras signaling pathways are well represented in their involvement in tumor initiation, but considerably less is known about their contribution to invasion and metastasis. In this review, we discuss the current evidence for mutant Ras proteins as significant players in these aspects of cancer progression. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：105 / 114

页数：10

共 132 条

[11] RAS ONCOGENE MEDIATED INDUCTION OF A 92KDA METALLOPROTEINASE - STRONG CORRELATION WITH THE MALIGNANT PHENOTYPE
BALLIN, M
GOMEZ, DE
SINHA, CC
THORGEIRSSON, UP
[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1988, 154 (03) : 832 - 838
[12] RAS GENES
BARBACID, M
[J]. ANNUAL REVIEW OF BIOCHEMISTRY, 1987, 56 : 779 - 827
[13] Characterization of Rac and Cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases
Benard, V
Bohl, BP
Bokoch, GM
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (19) : 13198 - 13204
[14] DIRECT EVIDENCE LINKING EXPRESSION OF MATRIX METALLOPROTEINASE-9 (92-KDA GELATINASE/COLLAGENASE) TO THE METASTATIC PHENOTYPE IN TRANSFORMED RAT EMBRYO CELLS
BERNHARD, EJ
GRUBER, SB
MUSCHEL, RJ
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (10) : 4293 - 4297
[15] Invasiveness of transformed human breast epithelial cell lines is related to cathepsin B and inhibited by cysteine proteinase inhibitors
Bervar, A
Zajc, I
Sever, N
Katunuma, N
Sloane, BF
Lah, TT
[J]. BIOLOGICAL CHEMISTRY, 2003, 384 (03) : 447 - 455
[16] The angiogenic regulator CD13/APN is a transcriptional target of Ras signaling pathways in endothelial morphogenesis
Bhagwat, SV
Petrovic, N
Okamoto, Y
Shapiro, LH
[J]. BLOOD, 2003, 101 (05) : 1818 - 1826
[17] INHIBITION OF COLLAGENOLYTIC ACTIVITY RELATES TO QUANTITATIVE REDUCTION OF INVASION IN-VITRO IN A C-HA-RAS TRANSFECTED GLIAL-CELL LINE
BOGHAERT, ER
CHAN, SK
ZIMMER, C
GROBELNY, D
GALARDY, RE
VANAMAN, TC
ZIMMER, SG
[J]. JOURNAL OF NEURO-ONCOLOGY, 1994, 21 (02) : 141 - 150
[18] BONDY GP, 1985, CANCER RES, V45, P6005
[19] INVASIVE AND METASTATIC POTENTIAL OF A V-HA-RAS-TRANSFORMED HUMAN BRONCHIAL EPITHELIAL-CELL LINE
BONFIL, RD
REDDEL, RR
URA, H
REICH, R
FRIDMAN, R
HARRIS, CC
KLEINSZANTO, AJP
[J]. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1989, 81 (08): : 587 - 594
[20] BOS JL, 1989, CANCER RES, V49, P4682

← 1 2 3 4 5 6 7 8 9 10 →