Stimulation of feeding behavior and food consumption in the goldfish, Carassius auratus, by orexin-A and orexin-B

被引：136

作者：

Volkoff, H ^{[1
]}

Bjorklund, JM ^{[1
]}

Peter, RE ^{[1
]}

机构：

[1] Univ Alberta, Dept Biol Sci, Edmonton, AB T6G 2E9, Canada

来源：

BRAIN RESEARCH | 1999年 / 846卷 / 02期

关键词：

orexin; feeding behavior; goldfish;

D O I：

10.1016/S0006-8993(99)02052-1

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The neuropeptides, orexin-A and orexin-B, have been demonstrated to have a physiological role in the regulation of food intake in mammals. The effects of human orexin-A and orexin-B intracerebroventricular (i.c.v.) injection on the feeding behavior of goldfish (Carassius auratus) were investigated. I.c.v. injection of orexin-A and orexin-B both caused a significant increase in appetite, as indicated by an increased number of feeding acts. Orexin-A and orexin-B both significantly stimulated food consumption, as indicated by increased total food intake during a 60-min observation period; the actions of orexin-A were dose dependent. Orexin-A was more potent than orexin-B in stimulation of both feeding behavior and food intake. These results indicate that orexin peptides are involved in the hypothalamic regulatory pathways of feeding behavior in goldfish. (C) 1999 Published by Elsevier Science B.V. All rights reserved.

引用

页码：204 / 209

页数：6

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