Obesity and Dyslipidemia

被引：30

作者：

Franssen, Remco ^{[1
]}

Monajemi, Houshang ^{[1
]}

Stroes, Erik S. G. ^{[1
]}

Kastelein, John J. P. ^{[1
]}

机构：

[1] Univ Amsterdam, Acad Med Ctr, Dept Vasc Med, NL-1105 AZ Amsterdam, Netherlands

来源：

ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA | 2008年 / 37卷 / 03期

关键词：

D O I：

10.1016/j.ecl.2008.06.003

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The alarming and still increasing prevalence of obesity and associated cardiovascular risk raises much concern. The increase in cardiovascular risk depends to a significant extent on the changes in lipid profiles as observed in obesity These changes are decreased high-density lipoprotein cholesterol and increased triglyceride levels. Much effort has already been expended into the elucidation of the mechanisms behind these obesity-associated lipid changes. Insulin resistance certainly plays a central role and, in addition, both hormonal and neurologic pathways have recently been found to play an important role. This article focuses on the mechanisms involved in the development of the proatherogenic lipid changes associated with obesity.

引用

页码：623 / +

页数：12

共 59 条

[11] INCREASED PLASMA CHOLESTERYL ESTER TRANSFER PROTEIN IN OBESE SUBJECTS - A POSSIBLE MECHANISM FOR THE REDUCTION OF SERUM HDL CHOLESTEROL LEVELS IN OBESITY [J].

ARAI, T ;

YAMASHITA, S ;

HIRANO, KI ;

SAKAI, N ;

KOTANI, K ;

FUJIOKA, S ;

NOZAKI, S ;

KENO, Y ;

YAMANE, M ;

SHINOHARA, E ;

ISLAM, AHMW ;

ISHIGAMI, M ;

NAKAMURA, T ;

KAMEDATAKEMURA, K ;

TOKUNAGA, K ;

MATSUZAWA, Y .

ARTERIOSCLEROSIS AND THROMBOSIS, 1994, 14 (07) :1129-1136

[12] Human fat cell lipolysis: Biochemistry, regulation and clinical role [J].

Arner, P .

BEST PRACTICE & RESEARCH CLINICAL ENDOCRINOLOGY & METABOLISM, 2005, 19 (04) :471-482

[13] Fasting compared with nonfasting triglycerides and risk of cardiovascular events in women [J].

Bansal, Sandeep ;

Buring, Julie E. ;

Rifai, Nader ;

Mora, Samia ;

Sacks, Frank M. ;

Ridker, Paul M. .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2007, 298 (03) :309-316

[14] Does gut hormone PYY3-36 decrease food intake in rodents?: Reply [J].

Batterham, RL ;

Cowley, MA ;

Small, CJ ;

Herzog, H ;

Cohen, MA ;

Dakin, CL ;

Wren, AM ;

Brynes, AE ;

Low, MJ ;

Ghatei, MA ;

Cone, RD ;

Bloom, SR .

NATURE, 2004, 430 (6996) :3-4

[15] ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism [J].

Berg, AH ;

Combs, TP ;

Scherer, PE .

TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2002, 13 (02) :84-89

[16] Adolescent overweight and future adult coronary heart disease [J].

Bibbins-Domingo, Kirsten ;

Coxson, Pamela ;

Pletcher, Mark J. ;

Lightwood, James ;

Goldman, Lee .

NEW ENGLAND JOURNAL OF MEDICINE, 2007, 357 (23) :2371-2379

[17] Adipose tissue selective insulin receptor knockout protects against obesity and obesity-related glucose intolerance [J].

Blüher, M ;

Michael, MD ;

Peroni, OD ;

Ueki, K ;

Carter, N ;

Kahn, BB ;

Kahn, CR .

DEVELOPMENTAL CELL, 2002, 3 (01) :25-38

[18]

Castelli W, 1998, Value Health, V1, P105, DOI 10.1046/j.1524-4733.1998.120105.x

[19] Adiponectinemia in visceral obesity:: Impact on glucose tolerance and plasma lipoprotein and lipid levels in men [J].

Côté, M ;

Mauriège, P ;

Bergeron, J ;

Alméras, N ;

Tremblay, A ;

Lemieux, I ;

Després, JP .

JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2005, 90 (03) :1434-1439

[20] The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis [J].

Cowley, MA ;

Smith, RG ;

Diano, S ;

Tschöp, M ;

Pronchuk, N ;

Grove, KL ;

Strasburger, CJ ;

Bidlingmaier, M ;

Esterman, M ;

Heiman, ML ;

Garcia-Segura, LM ;

Nillni, EA ;

Mendez, P ;

Low, MJ ;

Sotonyi, P ;

Friedman, JM ;

Liu, HY ;

Pinto, S ;

Colmers, WF ;

Cone, RD ;

Horvath, TL .

NEURON, 2003, 37 (04) :649-661

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