Translocation of tRNA during protein synthesis

被引：117

作者：

Noller, HF ^{[1
]}

Yusupov, MM

Yusupova, GZ

Baucom, A

Cate, JHD

机构：

[1] Univ Calif Santa Cruz, Sinsheimer Labs, Ctr Mol Biol RNA, Santa Cruz, CA 95064 USA

[2] Univ Calif Santa Cruz, Sinsheimer Labs, Dept Mol Cellular & Dev Biol, Santa Cruz, CA 95064 USA

[3] Lawrence Berkeley Natl Lab, Berkeley Ctr Struct Biol, Phys Biosci Div, Berkeley, CA 94720 USA

来源：

FEBS LETTERS | 2002年 / 514卷 / 01期

关键词：

ribosome; hybrid state; tRNA; mRNA; translocation; spirin;

D O I：

10.1016/S0014-5793(02)02327-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Coupled translocation of tRNA and mRNA in the ribosome during protein synthesis is one of the most challenging, and intriguing problems in the field of translation. We highlight several key questions regarding the mechanism of translocation, and discuss possible mechanistic models in light of the recent crystal structures of the ribosome and its subunits. (C) 2002 Published by Elsevier Science B.V. on behalf of the Federation of European Biochemical Societies.

引用

页码：11 / 16

页数：6