Mass spectrometry for the identification of the discriminating signals from metabolomics: Current status and future trends

被引：151

作者：

Werner, Erwan ^{[1
]}

Heilier, Jean-Francois ^{[1
,2
]}

Ducruix, Celine ^{[1
]}

Ezan, Eric ^{[1
]}

Junot, Christophe ^{[1
]}

Tabet, Jean-Claude ^{[3
]}

机构：

[1] CEA, DSV iBiTec S SPI, Lab Anal Metab Medicament, F-91191 Gif Sur Yvette, France

[2] Catholic Univ Louvain, Fac Med, Ind Toxicol & Occupat Med Unit, B-1200 Brussels, Belgium

[3] Univ Paris 06, CNRS, Lab Chim Struct Organ & Biol, UMR 7613, F-75005 Paris, France

来源：

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 2008年 / 871卷 / 02期

关键词：

metabolomics; metabonomics; identification; mass spectrometry;

D O I：

10.1016/j.jchromb.2008.07.004

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The metabolome is characterized by a large number of molecules exhibiting a high diversity of chemical structures and abundances, requiring complementary analytical platforms to reach its extensive Coverage. Among them, atmospheric pressure ionization mass spectrometry (API-MS)-based technologies, and especially those using electrospray ionization are now very popular. In this context. this review deals with strengths, limitations and future trends ill the identification of signals highlighted by API-MS-based metabolomics. It covers the identification process from the determination of the molecular mass and/or its elemental composition to the confirmation of structural hypotheses. Furthermore, some tools that were developed ill Order to address the MS signal redundancy and some approaches that could facilitate identification by improving the Visualization and organization of complex data sets are also reported and discussed. (C) 2008 Elsevier B.V. All rights reserved.

引用

页码：143 / 163

页数：21

共 208 条

[71] A mini-review of mass spectrometry using high-performance FTICR-MS methods [J].

Heeren, RMA ;

Kleinnijenhuis, AJ ;

McDonnell, LA ;

Mize, TH .

ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2004, 378 (04) :1048-1058

[72] Stable isotope assisted assignment of elemental compositions for metabolomics [J].

Hegeman, Adrian D. ;

Schulte, Christopher F. ;

Cui, Qiu ;

Lewis, Ian A. ;

Huttlin, Edward L. ;

Eghbalnia, Hamid ;

Harms, Amy C. ;

Ulrich, Eldon L. ;

Markley, John L. ;

Sussman, Michael R. .

ANALYTICAL CHEMISTRY, 2007, 79 (18) :6912-6921

[73] FOURIER-TRANSFORM MASS-SPECTROMETRY OF LARGE MOLECULES BY ELECTROSPRAY IONIZATION [J].

HENRY, KD ;

WILLIAMS, ER ;

WANG, BH ;

MCLAFFERTY, FW ;

SHABANOWITZ, J ;

HUNT, DF .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (23) :9075-9078

[74]

Holmes E, 1998, NMR BIOMED, V11, P235, DOI 10.1002/(SICI)1099-1492(199806/08)11:4/5<235::AID-NBM507>3.0.CO

[75]

2-V

[76] Chemometric contributions to the evolution of metabonomics: mathematical solutions to characterising and interpreting complex biological NMR spectra [J].

Holmes, E ;

Antti, H .

ANALYST, 2002, 127 (12) :1549-1557

[77] Triple quadrupole linear ion trap mass spectrometer for the analysis of small molecules and macromolecules [J].

Hopfgartner, G ;

Varesio, E ;

Tschäppät, V ;

Grivet, C ;

Bourgogne, E ;

Leuthold, LA .

JOURNAL OF MASS SPECTROMETRY, 2004, 39 (08) :845-855

[78]

Horai H., 2007, 55 ASMS C MASS SPECT

[79] The Orbitrap: a new mass spectrometer [J].

Hu, QZ ;

Noll, RJ ;

Li, HY ;

Makarov, A ;

Hardman, M ;

Cooks, RG .

JOURNAL OF MASS SPECTROMETRY, 2005, 40 (04) :430-443

[80] Rapid screening of anabolic steroids in urine by reactive Desorption Electrospray ionization [J].

Huang, Guangming ;

Chen, Hao ;

Zhang, Xinrong ;

Cooks, R. Graham ;

Ouyang, Zheng .

ANALYTICAL CHEMISTRY, 2007, 79 (21) :8327-8332

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