The changing landscape of ischaemic brain injury mechanisms

被引：933

作者：

Lee, JM ^{[1
]}

Zipfel, GJ

Choi, DW

机构：

[1] Washington Univ, Sch Med, Ctr Study Nervous Syst Injury, St Louis, MO 63110 USA

[2] Washington Univ, Sch Med, Dept Neurol, St Louis, MO 63110 USA

来源：

NATURE | 1999年 / 399卷 / 6738期

关键词：

D O I：

10.1038/399a007

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Thrombolysis has become established as an acute treatment for human stroke. But despite multiple clinical trials, neuroprotective strategies have yet to be proved effective in humans. Here we discuss intrinsic tissue mechanisms of ischaemic brain injury, and present a perspective that broadening of therapeutic targeting beyond excitotoxicity and neuronal calcium overload will be desirable for developing the most effective neuroprotective therapies.

引用

页码：A7 / A14

页数：8

共 100 条

[1] SELECTIVE MODULATION OF NMDA RESPONSES BY REDUCTION AND OXIDATION [J].

AIZENMAN, E ;

LIPTON, SA ;

LORING, RH .

NEURON, 1989, 2 (03) :1257-1263

[2] DO NMDA ANTAGONISTS PREVENT NEURONAL INJURY - YES [J].

ALBERS, GW ;

GOLDBERG, MP ;

CHOI, DW .

ARCHIVES OF NEUROLOGY, 1992, 49 (04) :418-420

[3]

AUER RN, 1993, DRUG DEV, V2, P307

[4] N-METHYL-D-ASPARTATE PROMOTES THE SURVIVAL OF CEREBELLAR GRANULE CELLS IN CULTURE [J].

BALAZS, R ;

JORGENSEN, OS ;

HACK, N .

NEUROSCIENCE, 1988, 27 (02) :437-451

[5] HUMAN EOSINOPHILS IN CULTURE UNDERGO A STRIKING AND RAPID SHRINKAGE DURING APOPTOSIS - ROLE OF K+ CHANNELS [J].

BEAUVAIS, F ;

MICHEL, L ;

DUBERTRET, L .

JOURNAL OF LEUKOCYTE BIOLOGY, 1995, 57 (06) :851-855

[6] Inflammation and acute stroke [J].

Becker, KJ .

CURRENT OPINION IN NEUROLOGY, 1998, 11 (01) :45-49

[7] ATTENUATION OF STROKE SIZE IN RATS USING AN ADENOVIRAL VECTOR TO INDUCE OVEREXPRESSION OF INTERLEUKIN-1 RECEPTOR ANTAGONIST IN BRAIN [J].

BETZ, AL ;

YANG, GY ;

DAVIDSON, BL .

JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 1995, 15 (04) :547-551

[8]

BINDOKAS VP, 1995, J NEUROSCI, V15, P6999

[9] APOPTOSIS AND NECROSIS - 2 DISTINCT EVENTS INDUCED, RESPECTIVELY, BY MILD AND INTENSE INSULTS WITH N-METHYL-D-ASPARTATE OR NITRIC-OXIDE SUPEROXIDE IN CORTICAL CELL-CULTURES [J].

BONFOCO, E ;

KRAINC, D ;

ANKARCRONA, M ;

NICOTERA, P ;

LIPTON, SA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (16) :7162-7166

[10] A primary role for K+ and Na+ efflux in the activation of apoptosis [J].

Bortner, CD ;

Hughes, FM ;

Cidlowski, JA .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (51) :32436-32442

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