Stereoselective intramolecular cycloadditions of homochiral nitrile imines:: synthesis of enantiomerically pure 3,3a-dihydro-pyrazolo[1,5-a][1,4] benzodiazepine-6(4H)-ones

被引：22

作者：

Broggini, G

Garanti, L

Molteni, G

Pilati, T

Ponti, A

Zecchi, G

机构：

[1] Univ Milan, Dipartimento Chim Organ & Ind, I-20133 Milan, Italy

[2] Univ Insubria, Dipartimento Sci Chim Fis & Matemat, I-22100 Como, Italy

[3] CNR, Ctr Studio Relaz Strutt & Reattiv Chim, I-20133 Milan, Italy

来源：

TETRAHEDRON-ASYMMETRY | 1999年 / 10卷 / 11期

关键词：

D O I：

10.1016/S0957-4166(99)00227-X

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

Starting from the commercially available (S)-1-phenylethylamine, we have synthesised the homochiral hydrazonoyl chlorides 4. The intramolecular cycloaddition of the corresponding nitrile imines 5 gave the diastereoisomeric 3,3a-dihydro-pyrazolo[ 1,5-a][1,4]benzodiazepine-6(4H)-ones 6 and 7 in enantiopure form. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：2203 / 2212

页数：10

共 29 条

[1] SIR92 - a program for automatic solution of crystal structures by direct methods [J].