Expression of transforming growth factor-α and epidermal growth factor receptor in gastrointestinal stromal tumours

被引：38

作者：

Cai, YC

Jiang, Z

Vittimberga, F

Xu, XW

Savas, L

Woda, B

Callery, M

Banner, B ^{[1
]}

机构：

[1] Univ Massachusetts Mem Hlth Care, Dept Pathol, Worcester, MA 01655 USA

[2] Univ Massachusetts Mem Hlth Care, Dept Surg, Worcester, MA 01655 USA

[3] Univ Massachusetts Mem Hlth Care, Dept Occupat Med, Worcester, MA 01655 USA

来源：

VIRCHOWS ARCHIV-AN INTERNATIONAL JOURNAL OF PATHOLOGY | 1999年 / 435卷 / 02期

关键词：

GIST; TGF-alpha; HER-1; HER-2; autocrine loop;

D O I：

10.1007/s004280050407

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Activation of epidermal growth factor receptor (EGFR) is associated with cell growth and transformation. Both transforming growth factor-alpha (TGF-alpha) and epidermal growth factor bind to and activate EGFR. We studied the expression of TGF-alpha and two EGFRs (HER-1 and HER-2) in gastrointestinal stromal tumours (GISTs) of the stomach (n=9) and small intestine (n=6) using standard immunostaining techniques in paraffin-embedded sections. Most GISTs expressed TGF-alpha, and a few expressed HER-1. All HER-1-positive tumours expressed TGF-alpha. These results suggest that a TGF-alpha/EGFR autocrine loop is present in GIST and that TGF-alpha promotes proliferation of GIST tumour cells through its interaction with HER-1 in at least some GISTs. This is the first description of an autocrine loop in GIST. In contrast, HER-2 is not expressed in any GIST.

引用

页码：112 / 115

页数：4

共 22 条

[1] Epidermal growth factor-related peptides activate distinct subsets of ErbB receptors and differ in their biological activities [J].