Genetic control of cortical regionalization and connectivity

被引：186

作者：

Rubenstein, JLR

Anderson, S

Shi, LM

Miyashita-Lin, E

Bulfone, A

Hevner, R

机构：

[1] Univ Calif San Francisco, Dept Psychiat, Ctr Neurobiol & Psychiat, Nina Ireland Lab Dev Neurobiol, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Program Neurosci, San Francisco, CA 94143 USA

[3] Univ Calif San Francisco, Program Dev Biol, San Francisco, CA 94143 USA

[4] Univ Calif San Francisco, Program Biomed Sci, San Francisco, CA 94143 USA

[5] Tigem Telethon Inst Genet & Med, I-20132 Milan, Italy

来源：

CEREBRAL CORTEX | 1999年 / 9卷 / 06期

关键词：

D O I：

10.1093/cercor/9.6.524

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Herein, the genetic control of regionalization and connectivity of the neocortex are reviewed. Evidence is accumulating which suggests that intrinsic mechanisms have a central role in controlling cortical regional specification and differentiation. Expression patterns of several genes (ld-2, Tbr-1, cadherin-6, cadherin-8, neuropilin-2, Wnt-7b, Eph-A7 and RZR-beta) are described; the expressions of these genes have regional boundaries which demarcate distint functional areas of the cerebral cortex in neonatal mice.

引用

页码：524 / 532

页数：9

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