Relationship Between Cyclophilin A Levels and Matrix Metalloproteinase 9 Activity in Cerebrospinal Fluid of Cognitively Normal Apolipoprotein E4 Carriers and Blood-Brain Barrier Breakdown

被引:99
作者
Halliday, Matthew R. [1 ,2 ]
Pomara, Nunzio [3 ]
Sagare, Abhay P. [2 ]
Mack, Wendy J. [4 ]
Frangione, Blas [3 ]
Zlokovic, Berislav V. [2 ]
机构
[1] Univ So Calif, Neurosci Grad Program, Los Angeles, CA 90089 USA
[2] Univ So Calif, Keck Sch Med, Zilkha Neurogenet Inst, Dept Physiol & Biophys,Ctr Neurodegenerat & Regen, Los Angeles, CA 90089 USA
[3] NYU, Sch Med, Dept Psychiat, Nathan S Kline Inst Psychiat Res, Orangeburg, NY USA
[4] Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90089 USA
关键词
ALZHEIMERS-DISEASE; DISORDERS;
D O I
10.1001/jamaneurol.2013.3841
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
[No abstract available]
引用
收藏
页码:1198 / 1200
页数:3
相关论文
共 9 条
[1]   Apolipoprotein E controls cerebrovascular integrity via cyclophilin A [J].
Bell, Robert D. ;
Winkler, Ethan A. ;
Singh, Itender ;
Sagare, Abhay P. ;
Deane, Rashid ;
Wu, Zhenhua ;
Holtzman, David M. ;
Betsholtz, Christer ;
Armulik, Annika ;
Sallstrom, Jan ;
Berk, Bradford C. ;
Zlokovic, Berislav V. .
NATURE, 2012, 485 (7399) :512-516
[2]  
BLENNOW K, 1990, ACTA NEUROL SCAND, V81, P323
[3]   Fibrinogen and Altered Hemostasis in Alzheimer's Disease [J].
Cortes-Canteli, Marta ;
Zamolodchikov, Daria ;
Ahn, Hyung Jin ;
Strickland, Sidney ;
Norris, Erin H. .
JOURNAL OF ALZHEIMERS DISEASE, 2012, 32 (03) :599-608
[4]   The APOE ε4/ε4 genotype potentiates vascular fibrin(ogen) deposition in amyloid-laden vessels in the brains of Alzheimer's disease patients [J].
Hultman, Karin ;
Strickland, Sidney ;
Norris, Erin H. .
JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM, 2013, 33 (08) :1251-1258
[5]   Lower CSF Amyloid Beta Peptides and Higher F2-lsoprostanes in Cognitively Intact Elderly Individuals With Major Depressive Disorder [J].
Pomara, Nunzio ;
Bruno, Davide ;
Sarreal, Antero S. ;
Hernando, Raymundo T. ;
Nierenberg, Jay ;
Petkova, Eva ;
Sidtis, John J. ;
Wisniewski, Thomas M. ;
Mehta, Pankaj D. ;
Pratico, Domenico ;
Zetterberg, Henrik ;
Blennow, Kaj .
AMERICAN JOURNAL OF PSYCHIATRY, 2012, 169 (05) :523-530
[6]   Apolipoprotein E in Alzheimer's disease and other neurological disorders [J].
Verghese, Philip B. ;
Castellano, Joseph M. ;
Holtzman, David M. .
LANCET NEUROLOGY, 2011, 10 (03) :241-252
[7]   Microvascular injury and blood-brain barrier leakage in Alzheimer's disease [J].
Zipser, B. D. ;
Johanson, C. E. ;
Gonzalez, L. ;
Berzin, T. M. ;
Tavares, R. ;
Hulette, C. M. ;
Vitek, M. P. ;
Hovanesian, V. ;
Stopa, E. G. .
NEUROBIOLOGY OF AGING, 2007, 28 (07) :977-986
[8]   Cerebrovascular Effects of Apolipoprotein E Implications for Alzheimer Disease [J].
Zlokovic, Berislav V. .
JAMA NEUROLOGY, 2013, 70 (04) :440-444
[9]   Neurovascular pathways to neurodegeneration in Alzheimer's disease and other disorders [J].
Zlokovic, Berislav V. .
NATURE REVIEWS NEUROSCIENCE, 2011, 12 (12) :723-738