MACiE: a database of enzyme reaction mechanisms

被引:37
作者
Holliday, GL
Bartlett, GJ
Almonacid, DE
O'Boyle, NM
Murray-Rust, P
Thornton, JM
Mitchell, JBO
机构
[1] Univ Cambridge, Dept Chem, Unilever Ctr Mol Sci Informat, Cambridge CB2 1EW, England
[2] EBI, EMBL, Cambridge CB10 1SD, England
基金
英国生物技术与生命科学研究理事会;
关键词
D O I
10.1093/bioinformatics/bti693
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
MACiE (mechanism, annotation and classification in enzymes) is a publicly available web-based database, held in CMLReact (an XML application), that aims to help our understanding of the evolution of enzyme catalytic mechanisms and also to create a classification system which reflects the actual chemical mechanism (catalytic steps) of an enzyme reaction, not only the overall reaction.
引用
收藏
页码:4315 / 4316
页数:2
相关论文
共 12 条
[1]   Analysis of catalytic residues in enzyme active sites [J].
Bartlett, GJ ;
Porter, CT ;
Borkakoti, N ;
Thornton, JM .
JOURNAL OF MOLECULAR BIOLOGY, 2002, 324 (01) :105-121
[2]   The Protein Data Bank [J].
Berman, HM ;
Westbrook, J ;
Feng, Z ;
Gilliland, G ;
Bhat, TN ;
Weissig, H ;
Shindyalov, IN ;
Bourne, PE .
NUCLEIC ACIDS RESEARCH, 2000, 28 (01) :235-242
[3]  
Holliday GL, 2004, INTERNET J CHEM, V7
[4]  
Ingold C. K., 1969, STRUCTURE MECH ORGAN
[5]   The KEGG resource for deciphering the genome [J].
Kanehisa, M ;
Goto, S ;
Kawashima, S ;
Okuno, Y ;
Hattori, M .
NUCLEIC ACIDS RESEARCH, 2004, 32 :D277-D280
[6]   EzCatDB: the Enzyme Catalytic-mechanism Database [J].
Nagano, N .
NUCLEIC ACIDS RESEARCH, 2005, 33 :D407-D412
[7]   CATH - a hierarchic classification of protein domain structures [J].
Orengo, CA ;
Michie, AD ;
Jones, S ;
Jones, DT ;
Swindells, MB ;
Thornton, JM .
STRUCTURE, 1997, 5 (08) :1093-1108
[8]  
Pegg SCH, 2005, PACIFIC SYMPOSIUM ON BIOCOMPUTING 2005, P358
[9]   The Catalytic Site Atlas: a resource of catalytic sites and residues identified in enzymes using structural data [J].
Porter, CT ;
Bartlett, GJ ;
Thornton, JM .
NUCLEIC ACIDS RESEARCH, 2004, 32 :D129-D133
[10]   BRENDA, the enzyme database: updates and major new developments [J].
Schomburg, I ;
Chang, A ;
Ebeling, C ;
Gremse, M ;
Heldt, C ;
Huhn, G ;
Schomburg, D .
NUCLEIC ACIDS RESEARCH, 2004, 32 :D431-D433