Lymphoid tissue inducer cells in adaptive CD4 T cell dependent responses

被引：18

作者：

Lane, Peter ^{[1
]}

Kim, Mi-Yeon ^{[1
]}

Withers, David ^{[1
]}

Gaspal, Fabrina ^{[1
]}

Bekiaris, Vasileios ^{[1
]}

Desanti, Guillaume ^{[1
]}

Khan, Mahmood ^{[1
]}

McConnell, Fiona ^{[1
]}

Anderson, Graham ^{[1
]}

机构：

[1] Univ Birmingham Sch Med, MRC, Inst Biomed Res, Ctr Immune Regulat, Birmingham B15 2TT, W Midlands, England

来源：

SEMINARS IN IMMUNOLOGY | 2008年 / 20卷 / 03期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

HIV; AIDS; CD4; memory; lymphoid tissue organization;

D O I：

10.1016/j.smim.2008.02.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Lymphoid tissue inducer cells (LTi) are known for their role in embryonic lymphoid tissue development. We have identified LTi in adult tissues including spleen and thymus, and provide evidence here for their presence in the submucosa of the intestine. From these observations it is clear that LTi play multiple roles in the adaptive immune system, notably the ability to recruit and sustain primed CD4 T cells in environments where they provide help to other cells. We speculate that their human equivalents could be potential targets for HIV infection and their destruction explains the pattern of loss of CD4 T cells. (c) 2008 Elsevier Ltd. All rights reserved.

引用

收藏

页码：159 / 163

页数：5

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