Physiologic Functions of Cyclophilin D and the Mitochondrial Permeability Transition Pore

被引：212

作者：

Elrod, John W. ^{[1
]}

Molkentin, Jeffery D. ^{[2
]}

机构：

[1] Temple Univ, Sch Med, Ctr Translat Med, Dept Pharmacol, Philadelphia, PA 19140 USA

[2] Univ Cincinnati, Dept Pediat, Cincinnati Childrens Hosp Med Ctr, Howard Hughes Med Inst, Cincinnati, OH 45221 USA

来源：

CIRCULATION JOURNAL | 2013年 / 77卷 / 05期

基金：

美国国家卫生研究院;

关键词：

Calcium; Cyclophilin D; Ischemic injury; Metabolism; Mitochondria; ADENINE-NUCLEOTIDE TRANSLOCASE; CA-2&-INDUCED MEMBRANE TRANSITION; COMPRISE VDAC MOLECULES; DEPENDENT ANION CHANNEL; CYCLOSPORINE-A; INNER MEMBRANE; CELL-DEATH; HEPATITIS-C; RAT-LIVER; CARDIAC-HYPERTROPHY;

D O I：

10.1253/circj.CJ-13-0321

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This review focuses on the role of cyclophilin D (CypD) as a prominent mediator of the mitochondrial permeability transition pore (MPTP) and subsequent effects on cardiovascular physiology and pathology. Although a great number of reviews have been written on the MPTP and its effects on cell death, we focus on the biology surrounding CypD itself and the non-cell death physiologic functions of the MPTP. A greater understanding of the physiologic functions of the MPTP and its regulation by CypD will likely suggest novel therapeutic approaches for cardiovascular disease, both dependent and independent of programmed necrotic cell death mechanisms. (Circ J 2013; 77: 1111-1122)

引用

页码：1111 / 1122

页数：12

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