MCM proteins in DNA replication

被引：544

作者：

Tye, BK ^{[1
]}

机构：

[1] Cornell Univ, Biochem Mol & Cell Biol Sect, Ithaca, NY 14853 USA

来源：

ANNUAL REVIEW OF BIOCHEMISTRY | 1999年 / 68卷

关键词：

DNA synthesis; cell cycle regulation; origin usage; pre-initiation complex; replication licensing; eukaryotes;

D O I：

10.1146/annurev.biochem.68.1.649

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The MCM proteins are essential replication initiation factors originally identified as proteins required for minichromosome maintenance in Saccharomyces cerevisiae. The best known among them are a family of six structurally related proteins, MCM2-7, which are evolutionally conserved in all eukaryotes. The MCM2-7 proteins form a hexameric complex. This complex is a key component of the prereplication complex that assembles at replication origins during early G1 phase. New evidence suggests that the MCM2-7 proteins may be involved not only in the initiation but also in the elongation of DNA replication. Orchestration of the functional interactions between the MCM2-7 proteins and other components of the prereplication complex by cell cycle-dependent protein kinases results in initiation of DNA synthesis once every cell cycle.

引用

页码：649 / 686

页数：38

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