Co-Crystals of the Anti-HIV Drugs Lamivudine and Zidovudine

被引：151

作者：

Bhatt, Prashant M. ^{[1
]}

Azim, Yasser ^{[1
]}

Thakur, Tejencer S. ^{[1
]}

Desiraju, Gautam R. ^{[1
]}

机构：

[1] Univ Hyderabad, Sch Chem, Hyderabad 500046, Andhra Pradesh, India

来源：

CRYSTAL GROWTH & DESIGN | 2009年 / 9卷 / 02期

关键词：

SOLID-STATE; CARBOXYLIC-ACIDS; PHARMACEUTICAL COCRYSTALS; SUPRAMOLECULAR SYNTHESIS; MOLECULAR RECOGNITION; ORGANIC ALLOYS; DESIGN; WATER; COMPLEXES; SYNTHON;

D O I：

10.1021/cg8007359

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Co-crystal forming abilities of the two anti-HIV drugs lamivudine and zidovudine were studied. A study of five crystal structures was carried out to investigate the general applicability of the retrosynthetic approach in the design of new co-crystals. This analysis of co-crystals and salt structures showed a complete to partial success, and in one case, a total failure to obtain the predicted synthon. Both screening strategies and rerrosynthetic methods may be appropriate for the discovery of new active pharmaceutical ingredients co-crystals.

引用

页码：951 / 957

页数：7

共 96 条

[1] Balancing intermolecular hydrogen-bond interactions for the directed assembly of binary 1:1 co-crystals [J].

Aakeroey, Christer B. ;

Schultheiss, Nate ;

Desper, John ;

Moore, Curtis .

NEW JOURNAL OF CHEMISTRY, 2006, 30 (10) :1452-1460

[2] Supramolecular reagents:: versatile tools for non-covalent synthesis [J].

Aakeröy, CB ;

Desper, J ;

Urbina, JF .

CHEMICAL COMMUNICATIONS, 2005, (22) :2820-2822

[3] Making reversible synthesis stick:: competition and cooperation between intermolecular interactions [J].

Aakeröy, CB ;

Desper, J ;

Elisabeth, E ;

Helfrich, BA ;

Levin, B ;

Urbina, JF .

ZEITSCHRIFT FUR KRISTALLOGRAPHIE, 2005, 220 (04) :325-332

[4] Building co-crystals with molecular sense and supramolecular sensibility [J].

Aakeröy, CB ;

Salmon, DJ .

CRYSTENGCOMM, 2005, 7 :439-448

[5] Do polymorphic compounds make good cocrystallizing agents?: A structural case study that demonstrates the importance of synthon flexibility [J].

Aakeröy, CB ;

Beatty, AM ;

Helfrich, BA ;

Nieuwenhuyzen, M .

CRYSTAL GROWTH & DESIGN, 2003, 3 (02) :159-165

[6]

Aakeröy CB, 2001, ANGEW CHEM INT EDIT, V40, P3240, DOI 10.1002/1521-3773(20010903)40:17<3240::AID-ANIE3240>3.0.CO

[7]

2-X

[8] Systematic analysis of the probabilities of formation of bimolecular hydrogen-bonded ring motifs in organic crystal structures [J].

Allen, FH ;

Motherwell, WDS ;

Raithby, PR ;

Shields, GP ;

Taylor, R .

NEW JOURNAL OF CHEMISTRY, 1999, 23 (01) :25-34

[9] Crystal engineering of the composition of pharmaceutical phases.: Do pharmaceutical co-crystals represent a new path to improved medicines? [J].

Almarsson, Ö ;

Zaworotko, MJ .

CHEMICAL COMMUNICATIONS, 2004, (17) :1889-1896

[10]

[Anonymous], 1998, SMART VERS 5 05

← 1 2 3 4 5 6 7 8 9 10 →