Co-Crystals of the Anti-HIV Drugs Lamivudine and Zidovudine

被引：151

作者：

Bhatt, Prashant M. ^{[1
]}

Azim, Yasser ^{[1
]}

Thakur, Tejencer S. ^{[1
]}

Desiraju, Gautam R. ^{[1
]}

机构：

[1] Univ Hyderabad, Sch Chem, Hyderabad 500046, Andhra Pradesh, India

来源：

CRYSTAL GROWTH & DESIGN | 2009年 / 9卷 / 02期

关键词：

SOLID-STATE; CARBOXYLIC-ACIDS; PHARMACEUTICAL COCRYSTALS; SUPRAMOLECULAR SYNTHESIS; MOLECULAR RECOGNITION; ORGANIC ALLOYS; DESIGN; WATER; COMPLEXES; SYNTHON;

D O I：

10.1021/cg8007359

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Co-crystal forming abilities of the two anti-HIV drugs lamivudine and zidovudine were studied. A study of five crystal structures was carried out to investigate the general applicability of the retrosynthetic approach in the design of new co-crystals. This analysis of co-crystals and salt structures showed a complete to partial success, and in one case, a total failure to obtain the predicted synthon. Both screening strategies and rerrosynthetic methods may be appropriate for the discovery of new active pharmaceutical ingredients co-crystals.

引用

页码：951 / 957

页数：7

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