SV40-positive brain tumor in scientist with risk of laboratory exposure to the virus

被引：19

作者：

Arrington, AS

Moore, MS

Butel, JS ^{[1
]}

机构：

[1] Baylor Coll Med, Dept Mol Virol & Microbiol, Houston, TX 77030 USA

[2] Baylor Coll Med, Dept Mol & Cellular Biol, Houston, TX 77030 USA

来源：

ONCOGENE | 2004年 / 23卷 / 12期

关键词：

brain tumor; meningioma; simian virus 40;

D O I：

10.1038/sj.onc.1207341

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Simian virus 40 ( SV40) is a DNA tumor virus known to induce cancers in laboratory animals. There are numerous reports of the detection of SV40 DNA and/ or proteins in human malignancies of the same types as those induced by SV40 in animals, including brain cancers. However, known exposure to the virus has not yet been linked directly to cancer development in a specific individual. Here we describe the detection of SV40 sequences in the meningioma of a laboratory researcher who had a probable direct exposure to SV40 and subsequently developed a tumor positive for viral DNA sequences indistinguishable from those of the laboratory source. This case suggests a link between viral exposure and tumor development.

引用

页码：2231 / 2235

页数：5

共 37 条

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Arrington AS, 2000, ANTICANCER RES, V20, P879

[2]

ARRINGTON AS, 2001, HUMAN POLYOMAVIRUSES, P461

[3] Human mesothelial cells are unusually susceptible to simian virus 40-mediated transformation and asbestos cocarcinogenicity [J].