Toll-like receptors and graft rejection

被引：11

作者：

Liu, Guangwei

Wu, You

Gong, Shouliang

Zhao, Yong

机构：

[1] Chinese Acad Sci, Inst Zool, State Key Lab Biomembrane & Membrane Biotechnol, Transplantat Biol Res Div, Beijing 100080, Peoples R China

[2] Jilin Univ, Sch Publ Hlth, Minist Hlth Radiobiol Res Unit, Changchun 130023, Peoples R China

来源：

TRANSPLANT IMMUNOLOGY | 2006年 / 16卷 / 01期

关键词：

Toll-like receptors; organ transplantation; graft rejection; innate immunity;

D O I：

10.1016/j.trim.2006.03.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Innate immunity plays a role in fighting against invading microorganisms. Emerging evidence suggests that in addition to responding to pathogen-associated molecular patterns of microorganisms, Toll-like receptors (TLRs) can be activated by endogenous ligands expressed by mammalian cells. Clinical and laboratory studies have shown that TLRs may participate in organ graft rejection and transplant immune tolerance, which are briefly reviewed in the present manuscript. (C) 2006 Elsevier B.V. All rights reserved.

引用

页码：25 / 31

页数：7

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