Intracellular determinants of picornavirus replication

被引：69

作者：

Andino, R ^{[1
]}

Boddeker, N ^{[1
]}

Gamarnik, AV ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Microbiol & Immunol, San Francisco, CA 94143 USA

来源：

TRENDS IN MICROBIOLOGY | 1999年 / 7卷 / 02期

关键词：

D O I：

10.1016/S0966-842X(98)01446-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Viruses replicate in a restricted number of hosts and tissues. In addition to viral receptors, several intracellular factors can be involved in determining tissue tropism. Many proteins have recently been implicated in picornavirus translation and RNA replication. Although the functional role of these proteins has not been established irt vivo, it is possible that they determine cell-type tropism and the pathogenic outcome of the infection.

引用

页码：76 / 82

页数：7

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