Are p27 and p21 Cytoplasmic Oncoproteins?

被引：134

作者：

Blagosklonny, Mikhail V. ^{[1
]}

机构：

[1] Brander Canc Res Inst, Med, 19 Bradhurst Ave,Suite 2400, Hawthorne, NY 10532 USA

来源：

CELL CYCLE | 2002年 / 1卷 / 06期

关键词：

p27; p21; Apoptosis; Tumor suppressor;

D O I：

10.4161/cc.1.6.262

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

By causing cytoplasmic mislocation of p27 and p21, the Akt oncogenic kinase functionally inactivates these nuclear tumor suppressor proteins. Is cytoplasmic localization of p27 and p21 simply equivalent to loss of their function or are new functions acquired in the cytoplasm? Indeed, several lines of evidence suggest that cytoplasmic p27 and p21 may be oncoproteins with antiapoptotic activities.

引用

页码：391 / 393

页数：3

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