Down-/up-conversion luminescence nanocomposites for dual-modal cell imaging

被引：62

作者：

An, Mingyue ^{[1
]}

Cui, Jiabin ^{[1
]}

He, Qian ^{[1
]}

Wang, Leyu ^{[1
]}

机构：

[1] Beijing Univ Chem Technol, Sch Sci, State Key Lab Chem Resource Engn, Beijing 100029, Peoples R China

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2013年 / 1卷 / 09期

基金：

中国国家自然科学基金;

关键词：

MULTIFUNCTIONAL NANOPARTICLES; QUANTUM DOTS; COLLOIDAL SPHERES; FLUORESCENCE; NANOCRYSTALS; CATALYST; MAGNETIZATION; NANOSPHERES; TOMOGRAPHY; NANOPROBES;

D O I：

10.1039/c2tb00469k

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

082905 [生物质能源与材料]; 100103 [病原生物学];

摘要：

Dual-modal luminescence nanocomposites (NCs) were successfully prepared via a facile and versatile strategy by embedding the hydrophobic down-conversion (DC) fluorescence ZnS:Mn2+ quantum dots (QDs) and up-conversion (UC) luminescence NaYF4:Er3+/Yb3+ nanoparticles (NPs) into hydrophilic polymer matrixes through in situ cross-linking polymerization. Due to the enriched carboxylic groups in the polymer matrixes, the as-prepared NCs are highly water-stable and bioconjugatable with chemical and biological moieties. The results of cytotoxicity assay and dual-modal luminescence cell imaging application of DC-UC NCs indicate that the as-prepared NCs are biocompatible and applicable in biomedical fields. The current work paves the way to the fabrication of multifunctional NCs including down- and up-conversion dual-modal luminescence, luminescence-magnetism, magnetic targeted drug vehicles and magnetic recyclable catalyst NCs, and will attract wide attention from the fields of chemistry, materials, catalysis, nanotechnology, nanobiotechnology and nanomedicine.

引用

页码：1333 / 1339

页数：7

共 67 条

[1]

Theranostic Nanoshells: From Probe Design to Imaging and Treatment of Cancer [J].