Carbene complexes of gold: preparation, medical application and bonding

被引:176
作者
Raubenheimer, Helgard G. [1 ]
Cronje, Stephanie [1 ]
机构
[1] Univ Stellenbosch, Dept Chem & Polymer Sci, ZA-7602 Matieland, South Africa
关键词
D O I
10.1039/b708636a
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
New preparative methods for gold carbene complexes have been developed and older ones modified to prepare compounds with specific inherent properties for targeted applications. One of the important areas of application that has grown rapidly and wherein carbene complexes are increasingly significant falls within the field of medicine. Sophisticated theoretical calculations have accompanied many synthetic studies. These aspects are covered in this critical review (65 references).
引用
收藏
页码:1998 / 2011
页数:14
相关论文
共 66 条
[1]  
[Anonymous], ORGANOMETALLICS
[2]   Looking for stable carbenes: The difficulty in starting anew [J].
Arduengo, AJ .
ACCOUNTS OF CHEMICAL RESEARCH, 1999, 32 (11) :913-921
[3]   NEW GOLD CARBENE COMPLEXES VIA CARBENE TRANSFER-REACTIONS [J].
AUMANN, R ;
FISCHER, EO .
CHEMISCHE BERICHTE-RECUEIL, 1981, 114 (05) :1853-1857
[4]   Cationic, linear Au(I) N-heterocyclic carbene complexes:: synthesis, structure and anti-mitochondrial activity [J].
Baker, Murray V. ;
Barnard, Peter J. ;
Berners-Price, Susan J. ;
Brayshaw, Simon K. ;
Hickey, James L. ;
Skelton, Brian W. ;
White, Allan H. .
DALTON TRANSACTIONS, 2006, (30) :3708-3715
[5]   Synthesis and structural characterisation of linear Au(I) N-heterocyclic carbene complexes: New analogues of the Au(I) phosphine drug Auranofin [J].
Baker, MV ;
Barnard, PJ ;
Berners-Price, SJ ;
Brayshaw, SK ;
Hickey, JL ;
Skelton, BW ;
White, AH .
JOURNAL OF ORGANOMETALLIC CHEMISTRY, 2005, 690 (24-25) :5625-5635
[6]   Synthetic, structural and spectroscopic studies of (pseudo)halo(1,3-di-tert-butylimidazol-2-ylidine) gold complexes [J].
Baker, MV ;
Barnard, PJ ;
Brayshaw, SK ;
Hickey, JL ;
Skelton, BW ;
White, AH .
DALTON TRANSACTIONS, 2005, (01) :37-43
[7]   Luminescence studies of the intracellular distribution of a dinuclear gold(I) N-heterocyclic carbene complex [J].
Barnard, Peter J. ;
Wedlock, Louise E. ;
Baker, Murray V. ;
Berners-Price, Susan J. ;
Joyce, David A. ;
Skelton, Brian W. ;
Steer, James H. .
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, 45 (36) :5966-5970
[8]   Dinuclear gold(I) complexes of bridging bidentate carbene ligands: synthesis, structure and spectroscopic characterisation [J].
Barnard, PJ ;
Baker, MV ;
Berners-Price, SJ ;
Skelton, BW ;
White, AH .
DALTON TRANSACTIONS, 2004, (07) :1038-1047
[9]   Carbenes with ferrocenyl substituents [J].
Bildstein, B .
JOURNAL OF ORGANOMETALLIC CHEMISTRY, 2001, 617 (01) :28-38
[10]   Synthesis of a transient tropylidene substituted N-heterocyclic carbene (tropNHC):: rearrangement and formation of its gold complex [J].
Böhler, C ;
Stein, D ;
Donati, N ;
Grützmacher, H .
NEW JOURNAL OF CHEMISTRY, 2002, 26 (10) :1291-1295