Titanium-catalyzed enantioselective alkynylation of aldehydes

被引：146

作者：

Lu, G

Li, XS

Chan, WL ^{[1
]}

Chan, ASC

机构：

[1] Hong Kong Polytech Univ, Inst Mol Technol Drug Discovery & Synth, Open Lab Chirotechnol, Hong Kong, Hong Kong, Peoples R China

[2] Hong Kong Polytech Univ, Dept Appl Biol & Chem Technol, Hong Kong, Hong Kong, Peoples R China

来源：

CHEMICAL COMMUNICATIONS | 2002年 / 02期

关键词：

D O I：

10.1039/b107817h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A simple and practical method to make chiral propargylic alcohols has been developed: in the presence of a titanium alkoxide catalyst prepared in situ from titanium tetraisopropoxide and (R)-H-8-binaphthol, a variety of aromatic aldehydes were converted to the corresponding chiral propargylic alcohols with very good enantioselectivities (up to 96.2% e.e.) and yields.

引用

页码：172 / 173

页数：2

共 27 条

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