New sesquiterpene derivatives from the red alga Laurencia scoparia.: Isolation, structure determination, and anthelmintic activity

被引：84

作者：

Davyt, D

Fernandez, R

Suescun, L

Mombrú, AW

Saldana, J

Domínguez, L

Coll, J

Fujii, MT

Manta, E

机构：

[1] Univ Republica, Fac Quim, Montevideo, Uruguay

[2] Inst Bot, BR-04301902 Sao Paulo, Brazil

来源：

JOURNAL OF NATURAL PRODUCTS | 2001年 / 64卷 / 12期

关键词：

D O I：

10.1021/np0102307

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Eleven sesquiterpenes (1-11) and one long chain aldehyde (12) have been isolated from the dichloromethane extract of the red alga Laurencia scoparia. Four of them are new natural products. Scopariol (1) is a new natural product with an unusual rearranged chamigrane-type structure, The other three are beta-chamigrenes: isorigidol (2), (+)-3-(Z)-bromomethylidene-10beta-bromo-beta-chamigrene (3), and (-)-3-(E)-bromomethylidene-10beta-bromo-beta-chamigrene (4), The in vitro activity of compounds 1-12 against the parasitant stage of Nippostrongylus brasiliensis (L4) has been studied.

引用

页码：1552 / 1555

页数：4

共 20 条

[1] A REARRANGED CHAMIGRENE DERIVATIVE AND ITS POTENTIAL BIOGENETIC PRECURSOR FROM A NEW SPECIES OF THE MARINE RED ALGAL GENUS LAURENCIA (RHODOMELACEAE) [J].