Daxx: death or survival protein?

被引：150

作者：

Salomoni, P ^{[1
]}

Khelifi, AF ^{[1
]}

机构：

[1] MRC, Toxicol Unit, Leicester LE1 9HN, Leics, England

来源：

TRENDS IN CELL BIOLOGY | 2006年 / 16卷 / 02期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/j.tcb.2005.12.002

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The death domain-associated protein (Daxx) was originally cloned as a CD95 (FAS)-interacting protein and modulator of FAS-induced cell death. Daxx accumulates in both the nucleus and the cytoplasm; in the nucleus, Daxx is found associated with the promyelocytic leukaemia (PML) nuclear body and with alpha-thalassemia/mental retardation syndrome protein (ATRX)-positive heterochromatic regions. In the cytoplasm, Daxx has been reported to interact with various proteins involved in cell death regulation. Despite a significant number of studies attempting to determine Daxx function in apoptotic and non-apoptotic cell death, its precise role in this process is only partially understood. Here, we critically review the current understanding of Daxx function and shed new light on this interesting field.

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页码：97 / 104

页数：8

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