Autophagy: Dual roles in life and death?

被引：834

作者：

Baehrecke, EH ^{[1
]}

机构：

[1] Univ Maryland, Maryland Biotechnol Inst, Ctr Biosyst Res, College Pk, MD 20742 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2005年 / 6卷 / 06期

基金：

美国国家航空航天局; 美国国家卫生研究院;

关键词：

D O I：

10.1038/nrm1666

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Autophagy is an evolutionarily conserved mechanism for the degradation of cellular components in the cytoplasm, and serves as a cell survival mechanism in starving cells. Recent studies indicate that autophagy also functions in cell death, but the precise role of this catabolic process in dying cells is not clear. Here I discuss the possible roles for autophagy in dying cells and how understanding the relationship between autophagy, cell survival and cell death is important for health and development.

引用

页码：505 / 510

页数：7

共 66 条

[1] Autophagy in human tumors: cell survival or death?
Alva, AS
Gultekin, SH
Baehrecke, EH
[J]. CELL DEATH AND DIFFERENTIATION, 2004, 11 (09) : 1046 - 1048
[2] Caspase activity and a specific cytochrome c are required for sperm differentiation in Drosophila
Arama, E
Agapite, J
Steller, H
[J]. DEVELOPMENTAL CELL, 2003, 4 (05) : 687 - 697
[3] The tumor suppressor PTEN positively regulates macroautophagy by inhibiting the phosphatidylinositol 3-kinase/protein kinase B pathway
Arico, S
Petiot, A
Bauvy, C
Dubbelhuis, PF
Meijer, AJ
Codogno, P
Ogier-Denis, E
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (38) : 35243 - 35246
[4] How death shapes life during development
Baehrecke, EH
[J]. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2002, 3 (10) : 779 - 787
[5] Inhibition of macroautophagy triggers apoptosis
Boya, P
González-Polo, RA
Casares, N
Perfettini, JL
Dessen, P
Larochette, N
Métivier, D
Meley, D
Souquere, S
Yoshimori, T
Pierron, G
Codogno, P
Kroemer, G
[J]. MOLECULAR AND CELLULAR BIOLOGY, 2005, 25 (03) : 1025 - 1040
[6] The phosphoinositide 3-kinase pathway
Cantley, LC
[J]. SCIENCE, 2002, 296 (5573) : 1655 - 1657
[7] Apaf1 (CED-4 homolog) regulates programmed cell death in mammalian development
Cecconi, F
Alvarez-Bolado, G
Meyer, BI
Roth, KA
Gruss, P
[J]. CELL, 1998, 94 (06) : 727 - 737
[8] Interdigital cell death can occur through a necrotic and caspase-independent pathway
Chautan, M
Chazal, G
Cecconi, F
Gruss, P
Golstein, P
[J]. CURRENT BIOLOGY, 1999, 9 (17) : 967 - 970
[9] Pleiotropic defects in lymphocyte activation caused by caspase-8 mutations lead to human immunodeficiency
Chun, HJ
Zheng, LX
Ahmad, M
Wang, J
Speirs, CK
Siegel, RM
Dale, MK
Puck, J
Davis, J
Hall, CG
Skoda-Smith, S
Atkinson, TP
Straus, SE
Lenardo, MJ
[J]. NATURE, 2002, 419 (6905) : 395 - 399
[10] DEVELOPMENTAL CELL-DEATH - MORPHOLOGICAL DIVERSITY AND MULTIPLE MECHANISMS
CLARKE, PGH
[J]. ANATOMY AND EMBRYOLOGY, 1990, 181 (03): : 195 - 213

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