Drug-induced hypertriglyceridemia with and without pancreatitis

被引：21

作者：

Keung, YK

Rizk, R

Wu, XY

Cobos, E

机构：

[1] Texas Tech Univ, Hlth Sci Ctr, Div Hematol Oncol, Lubbock, TX 79430 USA

[2] Texas Tech Univ, Hlth Sci Ctr, Div Gastroenterol, Lubbock, TX 79430 USA

[3] Texas Tech Univ, Hlth Sci Ctr, Dept Internal Med, Lubbock, TX 79430 USA

[4] Texas Tech Univ, Hlth Sci Ctr, Dept Psychiat, Lubbock, TX 79430 USA

来源：

SOUTHERN MEDICAL JOURNAL | 1999年 / 92卷 / 09期

关键词：

D O I：

10.1097/00007611-199909000-00013

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We describe two cases of drug-induced hypertriglyceridemia, one associated with interferon alfa-2b and the other with asparaginase, each of which is mediated through a different mechanism, Hypertriglyceridemia caused by these medications is not listed as an adverse reaction in the Physicians' Desk Reference, one of the most popular pharmacologic reference sources used in the United States. We emphasize the importance of early recognition of this metabolic effect and the potential life-threatening complication, acute pancreatitis.

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收藏

页码：912 / 914

页数：3

相关论文

共 27 条

[1] HYPERTRIGLYCERIDEMIA DURING LONG-TERM INTERFERON-ALPHA THERAPY - EFFICACY OF DIET AND GEMFIBROSIL TREATMENT - A CASE-REPORT [J].

BERRUTI, A ;

GORZEGNO, G ;

VITETTA, G ;

TAMPELLINI, M ;

DOGLIOTTI, L .

TUMORI JOURNAL, 1992, 78 (05) :353-355

[2] SOMATOSTATIN THERAPY IN L-ASPARAGINASE-INDUCED PANCREATITIS [J].

CHEUNG, YF ;

LEE, CW ;

CHAN, CF ;

CHAN, KL ;

LAU, YL ;

YEUNG, CY .

MEDICAL AND PEDIATRIC ONCOLOGY, 1994, 22 (06) :421-424

[3] THE EFFECT OF L-ASPARAGINASE ON LIPID-METABOLISM DURING INDUCTION CHEMOTHERAPY OF CHILDHOOD LYMPHOBLASTIC-LEUKEMIA [J].

CREMER, P ;

LAKOMEK, M ;

BECK, W ;

PRINDULL, G .

EUROPEAN JOURNAL OF PEDIATRICS, 1988, 147 (01) :64-67

[4]

Garrington T, 1998, MED PEDIATR ONCOL, V30, P106, DOI 10.1002/(SICI)1096-911X(199802)30:2<106::AID-MPO7>3.0.CO

[5]

2-M

[6] ALPHA-INTERFERON AND REVERSIBLE HYPERTRIGLYCERIDEMIA [J].

GRAESSLE, D ;

BONACINI, M ;

CHEN, S .

ANNALS OF INTERNAL MEDICINE, 1993, 118 (04) :316-317

[7] Transient hyperlipidemia during treatment of ALL with L-asparaginase is related to decreased lipoprotein lipase activity [J].

Hoogerbrugge, N ;

Jansen, H ;

Hoogerbrugge, PM .

LEUKEMIA, 1997, 11 (08) :1377-1379

[8] Interferon alfa-2b adjuvant therapy of high-risk resected cutaneous melanoma: The Eastern Cooperative Oncology Group trial EST 1684 [J].

Kirkwood, JM ;

Strawderman, MH ;

Ernstoff, MS ;

Smith, TJ ;

Borden, EC ;

Blum, RH .

JOURNAL OF CLINICAL ONCOLOGY, 1996, 14 (01) :7-17

[9] RECOMBINANT GAMMA-INTERFERON INDUCES HYPERTRIGLYCERIDEMIA AND INHIBITS POSTHEPARIN LIPASE ACTIVITY IN CANCER-PATIENTS [J].

KURZROCK, R ;

ROHDE, MF ;

QUESADA, JR ;

GIANTURCO, SH ;

BRADLEY, WA ;

SHERWIN, SA ;

GUTTERMAN, JU .

JOURNAL OF EXPERIMENTAL MEDICINE, 1986, 164 (04) :1093-1101

[10]

LAND VJ, 1972, CANCER, V30, P339, DOI 10.1002/1097-0142(197208)30:2<339::AID-CNCR2820300206>3.0.CO