Multiple sclerosis

被引：317

作者：

Hafler, DA

机构：

[1] Harvard Univ, Sch Med, Boston, MA 02115 USA

[2] Brigham & Womens Hosp, Ctr Neurol Dis, Lab Mol Immunol, Boston, MA 02115 USA

[3] MIT, Broad Inst, Cambridge, MA USA

[4] Harvard Univ, Cambridge, MA 02138 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2004年 / 113卷 / 06期

关键词：

D O I：

10.1172/JCI200421357

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Multiple sclerosis is a complex genetic disease associated with inflammation in the CNS white matter thought to be mediated by autoreactive T cells. Clonal expansion of B cells, their antibody products, and T cells, hallmarks of inflammation in the CNS, are found in MS. This review discusses new methods to define the molecular pathology of human disease with high-throughput examination of germline DNA haplotypes, RNA expression, and protein structures that will allow the generation of a new series of hypotheses that can be tested to develop better understanding of and therapies for this disease.

引用

页码：788 / 794

页数：7

共 95 条

[1] ACHIRON A, 2000, ARCH NEUROL-CHICAGO, V57, P947
[2] ASSOCIATION OF SUSCEPTIBILITY TO MULTIPLE-SCLEROSIS IN SWEDEN WITH HLA CLASS-II DRB1 AND DQB1 ALLELES
ALLEN, M
SANDBERGWOLLHEIM, M
SJOGREN, K
ERLICH, HA
PETTERSON, U
GYLLENSTEN, U
[J]. HUMAN IMMUNOLOGY, 1994, 39 (01) : 41 - 48
[3] ALPEROVITCH A, 1992, ANN NEUROL, V32, P724
[4] Ausubel LJ, 1997, J IMMUNOL, V159, P2502
[5] Cross-reactivity of T-cell clones specific for altered peptide ligands of myelin basic protein
Ausubel, LJ
Bieganowska, KD
Hafler, DA
[J]. CELLULAR IMMUNOLOGY, 1999, 193 (01) : 99 - 107
[6] Complementary mutations in an antigenic peptide allow for crossreactivity of autoreactive T-cell clones
Ausubel, LJ
Kwan, CK
Sette, A
Kuchroo, V
Hafler, DA
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (26) : 15317 - 15322
[7] RELAPSING-REMITTING MULTIPLE-SCLEROSIS - SEQUENTIAL ENHANCED MR IMAGING VS CLINICAL FINDINGS IN DETERMINING DISEASE-ACTIVITY
BARKHOF, F
SCHELTENS, P
FREQUIN, STFM
NAUTA, JJP
TAS, MW
VALK, J
HOMMES, OR
[J]. AMERICAN JOURNAL OF ROENTGENOLOGY, 1992, 159 (05) : 1041 - 1047
[8] THE RAPID ISOLATION OF CLONABLE ANTIGEN-SPECIFIC LYMPHOCYTE-T LINES CAPABLE OF MEDIATING AUTOIMMUNE ENCEPHALOMYELITIS
BENNUN, A
WEKERLE, H
COHEN, IR
[J]. EUROPEAN JOURNAL OF IMMUNOLOGY, 1981, 11 (03) : 195 - 199
[9] Encephalitogenic potential of the myelin basic protein peptide (amino acids 83-99) in multiple sclerosis: Results of a phase II clinical trial with an altered peptide ligand
Bielekova, B
Goodwin, B
Richert, N
Cortese, I
Kondo, T
Afshar, G
Gran, B
Eaton, J
Antel, J
Frank, JA
McFarland, HF
Martin, R
[J]. NATURE MEDICINE, 2000, 6 (10) : 1167 - 1175
[10] A PLACEBO-CONTROLLED, DOUBLE-BLIND, RANDOMIZED, 2-CENTER, PILOT TRIAL OF COP 1 IN CHRONIC PROGRESSIVE MULTIPLE-SCLEROSIS
BORNSTEIN, MB
MILLER, A
SLAGLE, S
WEITZMAN, M
DREXLER, E
KEILSON, M
SPADA, V
WEISS, W
APPEL, S
ROLAK, L
HARATI, Y
BROWN, S
ARNON, R
JACOBSOHN, I
TEITELBAUM, D
SELA, M
[J]. NEUROLOGY, 1991, 41 (04) : 533 - 539

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