Multiple sclerosis

被引：317

作者：

Hafler, DA

机构：

[1] Harvard Univ, Sch Med, Boston, MA 02115 USA

[2] Brigham & Womens Hosp, Ctr Neurol Dis, Lab Mol Immunol, Boston, MA 02115 USA

[3] MIT, Broad Inst, Cambridge, MA USA

[4] Harvard Univ, Cambridge, MA 02138 USA

来源：

JOURNAL OF CLINICAL INVESTIGATION | 2004年 / 113卷 / 06期

关键词：

D O I：

10.1172/JCI200421357

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Multiple sclerosis is a complex genetic disease associated with inflammation in the CNS white matter thought to be mediated by autoreactive T cells. Clonal expansion of B cells, their antibody products, and T cells, hallmarks of inflammation in the CNS, are found in MS. This review discusses new methods to define the molecular pathology of human disease with high-throughput examination of germline DNA haplotypes, RNA expression, and protein structures that will allow the generation of a new series of hypotheses that can be tested to develop better understanding of and therapies for this disease.

引用

页码：788 / 794

页数：7

共 95 条

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