Regulation of DNA repair by ubiquitylation

被引：214

作者：

Huang, TT

D'Andrea, AD

机构：

[1] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Radiat Oncol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dana Farber Canc Inst, Dept Pediat Oncol, Boston, MA 02115 USA

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2006年 / 7卷 / 05期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrm1908

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The process of ubiquitylation is best known for its role in targeting proteins for degradation by the proteasome. However, recent studies of DNA-repair and DNA-damage-response pathways have significantly broadened the scope of the role of ubiquitylation to include non-proteolytic functions of ubiquitin. These pathways involve the monoubiquitylation of key DNA-repair proteins that have regulatory functions in homologous recombination and translesion DNA synthesis, and involve the polyubiquitylation of nucleotide-excision-repair proteins.

引用

收藏

页码：323 / 334

页数：12

相关论文

共 105 条

[1] Mechanism and function of deubiquitinating enzymes [J].

Amerik, AY ;

Hochstrasser, M .

BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2004, 1695 (1-3) :189-207

[2] ATR couples FANCD2 monoubiquitination to the DNA-damage response [J].

Andreassen, PR ;

D'Andrea, AD ;

Taniguchi, T .

GENES & DEVELOPMENT, 2004, 18 (16) :1958-1963

[3] Ubiquitin-binding domains in Y-family polymerases regulate translesion synthesis [J].

Bienko, M ;

Green, CM ;

Crosetto, N ;

Rudolf, F ;

Zapart, G ;

Coull, B ;

Kannouche, P ;

Wider, G ;

Peter, M ;

Lehmann, AR ;

Hofmann, K ;

Dikic, I .

SCIENCE, 2005, 310 (5755) :1821-1824

[4] UV-induced ubiquitination of RNA polymerase II: A novel modification deficient in cockayne syndrome cells [J].

Bregman, DB ;

Halaban, R ;

vanGool, AJ ;

Henning, KA ;

Friedberg, EC ;

Warren, SL .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (21) :11586-11590

[5] Ubiquitin signalling in the NF-κB pathway [J].

Chen, ZJJ .

NATURE CELL BIOLOGY, 2005, 7 (08) :758-U19

[6]

Chiba N, 2002, CANCER RES, V62, P4222

[7] Cancer in xeroderma pigmentosum and related disorders of DNA repair [J].

Cleaver, JE .

NATURE REVIEWS CANCER, 2005, 5 (07) :564-573

[8] COP9 signalosome: A multifunctional regulator of SCF and other cullin-based ubiquitin Ligases [J].

Cope, GA ;

Deshaies, RJ .

CELL, 2003, 114 (06) :663-671

[9] Role of predicted metalloprotease motif of Jab1/Csn5 in cleavage of Nedd8 from Cul1 [J].

Cope, GA ;

Suh, GSB ;

Aravind, L ;

Schwarz, SE ;

Zipursky, SL ;

Koonin, EV ;

Deshaies, RJ .

SCIENCE, 2002, 298 (5593) :608-611

[10] The Fanconi anaemia BRCA pathway [J].

D'Andrea, AD ;

Grompe, M .

NATURE REVIEWS CANCER, 2003, 3 (01) :23-34

← 1 2 3 4 5 6 7 8 9 10 →