共 13 条
CASP8 results in context of previous experiments
被引:28
作者:

Kryshtafovych, Andriy
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif Davis, Genome Ctr, Davis, CA 95616 USA Univ Calif Davis, Genome Ctr, Davis, CA 95616 USA

Fidelis, Krzysztof
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Calif Davis, Genome Ctr, Davis, CA 95616 USA Univ Calif Davis, Genome Ctr, Davis, CA 95616 USA

Moult, John
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Maryland, Inst Biotechnol, Ctr Adv Res Biotechnol, Rockville, MD 20850 USA Univ Calif Davis, Genome Ctr, Davis, CA 95616 USA
机构:
[1] Univ Calif Davis, Genome Ctr, Davis, CA 95616 USA
[2] Univ Maryland, Inst Biotechnol, Ctr Adv Res Biotechnol, Rockville, MD 20850 USA
关键词:
protein structure prediction;
community wide experiment;
CASP;
progress;
PROTEIN;
PROGRESS;
QUALITY;
MODELS;
D O I:
10.1002/prot.22562
中图分类号:
Q5 [生物化学];
Q7 [分子生物学];
学科分类号:
071010 ;
081704 ;
摘要:
The quality of structure models submitted to CASP8 is analyzed in the context of previous CASPs. To compare models from the latest experiment with their predecessors, we use the approaches consistent with the previous articles in this series. Using the basic evaluation measures accepted in CASP, there were no noticeable advances in the quality of the methods in any of the target difficulty categories. At the same time, there were three positive developments: (1) for set of the best models on each target, CASP8 registered the highest number of cases from all CASPs where alignment accuracy exceeded the maximum possible from the best template; (2) modeling accuracy of regions not present in the best template has improved; and (3) the loss in modeling quality from selection of nonoptimal models as the best ones submitted on the target has decreased.
引用
收藏
页码:217 / 228
页数:12
相关论文
共 13 条
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Univ N Carolina, Dept Biochem & Biophys, Chapel Hill, NC 27599 USA Univ Basel, Biozentrum, Swiss Inst Bioinformat, CH-4056 Basel, Switzerland

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Huang, Yuanpeng Janet
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Univ Calif San Francisco, Dept Pharmaceut Chem, San Francisco, CA 94158 USA Univ Basel, Biozentrum, Swiss Inst Bioinformat, CH-4056 Basel, Switzerland

Joachimiak, Andrzej
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Argonne Natl Lab, Biosci Div, Midwest Ctr Struct Genom, Argonne, IL 60439 USA
Argonne Natl Lab, Biosci Div, Struct Biol Ctr, Argonne, IL 60439 USA Univ Basel, Biozentrum, Swiss Inst Bioinformat, CH-4056 Basel, Switzerland

Krystek, Stanley R., Jr.
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Kortemme, Tanja
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Rutgers State Univ, Ctr Adv Res Biotechnol, Dept Biochem & Mol Biol, Piscataway, NJ 08854 USA Univ Basel, Biozentrum, Swiss Inst Bioinformat, CH-4056 Basel, Switzerland

Moult, John
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Univ Maryland, Maryland Biotechnol Inst, Ctr Adv Res Biotechnol, Rockville, MD 20850 USA Univ Basel, Biozentrum, Swiss Inst Bioinformat, CH-4056 Basel, Switzerland

Murray, Diana
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Boston Univ, Biomed Engn Struct Bioinformat Lab, Boston, MA 02215 USA Univ Basel, Biozentrum, Swiss Inst Bioinformat, CH-4056 Basel, Switzerland

Vasquez, Max
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Westbrook, John D.
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Rutgers State Univ, Prot Data Bank, Res Collaboratory Struct Bioinformat, Piscataway, NJ 08854 USA
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机构: Univ Maryland, Maryland Biotechnol Inst, Ctr Adv Res Biotechnol, Rockville, MD 20850 USA

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机构: Univ Maryland, Maryland Biotechnol Inst, Ctr Adv Res Biotechnol, Rockville, MD 20850 USA

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机构: Univ Maryland, Maryland Biotechnol Inst, Ctr Adv Res Biotechnol, Rockville, MD 20850 USA